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GRO-α/CXCR2 System and ADAM17 Correlated Expression in Sjögren’s Syndrome

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Abstract

The chemokine GRO-α and its receptor CXCR2 are associated with the chronic inflammation in Sjögren’s syndrome (SS). To better understand the molecular mechanisms by which the GRO-α/CXCR2 system is involved in the SS inflammatory condition, our studies were designed to clarify the role of ADAM17 activation in the modulation of the GRO-α/CXCR2 chemokine system in epithelial cells (SGEC) from SS salivary glands. The CXCR2 overexpression observed in SS SGEC was dramatically decreased by ADAM17 inhibitor TAPI-1. In addition, comparing the expression levels of ADAM17 in healthy SGEC in presence or not of GRO-α treatment, we observed that GRO-α dose-dependently influences ADAM17 activation, an effect that was inhibited by blocking the interaction of GRO-α with its CXCR2 receptor. Our data show for the first time that ADAM17 has an important role in GRO-α/CXCR2 system activity regulation, suggesting that regulating CXCR2/ADAM17 interaction could be an attractive therapeutic target in SS.

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Acknowledgments

We are grateful to M.V.C. Pragnell, B.A., a professional scientific text editor, for critical reading of the manuscript and language revision.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Section of Human Anatomy and Histology, Laboratory of Cell Biology, University of Bari Medical School, Bari, Italy

    Sabrina Lisi, Margherita Sisto, Raffaella De Lucro & Domenico Ribatti

  2. Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy

    Dario Domenico Lofrumento

  3. Interdisciplinary Department of Medicine, Section of Rheumatology, University of Bari Medical School, Bari, Italy

    Massimo D’Amore

Authors
  1. Sabrina Lisi
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  2. Margherita Sisto
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  3. Dario Domenico Lofrumento
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  4. Massimo D’Amore
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  5. Raffaella De Lucro
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  6. Domenico Ribatti
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Correspondence to Sabrina Lisi.

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Sabrina Lisi and have Margherita Sisto have equal contribution in this work and both are equally considered as “first author”.

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Lisi, S., Sisto, M., Lofrumento, D.D. et al. GRO-α/CXCR2 System and ADAM17 Correlated Expression in Sjögren’s Syndrome. Inflammation 36, 759–766 (2013). https://doi.org/10.1007/s10753-013-9602-6

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