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Association of Body Fat with Inflammation in Peritoneal Dialysis

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Abstract

Peritoneal dialysis (PD) frequently leads to body weight gain, which appears to be a potential cause of the chronic inflammation frequently present in these patients. The consequences of this inflammation are impaired nutritional status, accelerated atherosclerosis, and increased mortality. To assess the association between inflammation and body fat in female patients treated with PD. Nineteen female patients on PD for at least 6 months with no infectious complications or malignant or acute inflammatory diseases. Nutritional status was determined by measuring weight, height, body mass index (BMI), waist (WC), and mid-arm circumferences (MAC), mid-arm muscle area, and tricipital fold (TCF). Bioelectrical impedance (BIA) was used to determine body composition. Biochemical evaluation included the determination of serum albumin, urea, creatinine, and C-reactive protein (CRP). The glucose absorbed from the dialysis solution was quantitated. According to BMI, two patients were classified as malnourished and ten as overweight/obese. Sixteen individuals had high WC measurements and 12 had excess body fat (BF) as measured by BIA. High CRP levels were observed in 12 patients, who had higher WC, MAC, BMI, TCF, and BF measurements compared to non-inflamed patients. Positive associations were detected between CRP and BMI, MAC, WC, and TCF. Associations between BF and CRP suggest that adiposity may be a potent exacerbating factor of inflammation in this population, especially visceral fat. Thus, obesity may be considered to be one more factor responsible for the early atherosclerosis and high cardiovascular mortality observed in these patients.

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ACKNOWLEDGMENTS

The authors thank National Council for Scientific and Technological Development (CNPq) for grant support.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil

    Andresa Marques de Mattos, Alceu Afonso Jordão, José Abrão Cardeal da Costa & Paula Garcia Chiarello

  2. Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenue Bandeirantes, 3900, Ribeirao Preto, São Paulo, 14049-900, Brazil

    Andresa Marques de Mattos & Paula Payão Ovidio

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  1. Andresa Marques de Mattos
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  2. Paula Payão Ovidio
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Correspondence to Andresa Marques de Mattos.

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de Mattos, A.M., Ovidio, P.P., Jordão, A.A. et al. Association of Body Fat with Inflammation in Peritoneal Dialysis. Inflammation 36, 689–695 (2013). https://doi.org/10.1007/s10753-013-9593-3

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  • DOI: https://doi.org/10.1007/s10753-013-9593-3

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