, Volume 35, Issue 6, pp 1900–1903 | Cite as

Acute Effect of Aloe vera Gel Extract on Experimental Models of Pain

  • Naveen Rathor
  • Ashish K. Mehta
  • Amit K. Sharma
  • Pramod K. MedirattaEmail author
  • Krishna K. Sharma


The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central.


Aloe vera tail-flick test formalin test inflammatory pain 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Naveen Rathor
    • 1
  • Ashish K. Mehta
    • 2
  • Amit K. Sharma
    • 1
  • Pramod K. Mediratta
    • 1
    Email author
  • Krishna K. Sharma
    • 1
  1. 1.Department of PharmacologyUniversity College of Medical Sciences (University of Delhi)DelhiIndia
  2. 2.Department of PhysiologyUniversity College of Medical SciencesDelhiIndia

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