Advertisement

Inflammation

, Volume 35, Issue 6, pp 1900–1903 | Cite as

Acute Effect of Aloe vera Gel Extract on Experimental Models of Pain

  • Naveen Rathor
  • Ashish K. Mehta
  • Amit K. Sharma
  • Pramod K. MedirattaEmail author
  • Krishna K. Sharma
Article

Abstract

The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central.

KEY WORDS

Aloe vera tail-flick test formalin test inflammatory pain 

References

  1. 1.
    Das, S., B. Mishra, K. Gill, M.S. Ashraf, A.K. Singh, M. Sinha, S. Sharma, I. Xess, K. Dalal, T.P. Singh, and S. Dey. 2011. Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel. International Journal of Biological Macromolecules 48: 38–43.PubMedCrossRefGoogle Scholar
  2. 2.
    Rajasekaran, S., K. Sivagnanam, K. Ravi, and S. Subramanian. 2005. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacological Reports 57: 90–96.PubMedGoogle Scholar
  3. 3.
    Rajasekaran, S., K. Ravi, K. Sivagnanam, and S. Subramanian. 2006. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clinical and Experimental Pharmacology and Physiology 33: 232–237.PubMedCrossRefGoogle Scholar
  4. 4.
    Hamman, J.H. 2008. Composition and applications of Aloe vera leaf gel. Molecules 13: 1599–1616.PubMedCrossRefGoogle Scholar
  5. 5.
    Choi, S.W., B.W. Son, Y.S. Son, Y.I. Park, S.K. Lee, and M.H. Chung. 2001. The wound healing effect of a glycoprotein fraction isolated from Aloe vera. British Journal of Dermatology 145: 535–545.PubMedCrossRefGoogle Scholar
  6. 6.
    Kim, J., I.S. Lee, S. Park, and R. Choue. 2010. Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and cytokine levels in atopic dermatitis NC/Nga mice. Journal of Ethnopharmacology 132: 529–532.PubMedCrossRefGoogle Scholar
  7. 7.
    Penneys, N.S. 1981. Inhibition of arachidonic acid oxidation by vehicle components. Acta Dermatology and Venereology 62: 59–61.Google Scholar
  8. 8.
    Heggers, J.P., A. Kucukcelebi, D. Listengarten, J. Stabenau, F. Ko, L.D. Broemeling, et al. 1996. Beneficial effect of Aloe on wound healing in an excisional wound model. Journal of Alternative and Complementary Medicine 2: 271–277.CrossRefGoogle Scholar
  9. 9.
    Prabjone, R., D. Thong-Ngam, N. Wisedopas, T. Chatsuwan, and S. Patumraj. 2006. Anti-inflammatory effects of Aloe vera on leukocyte–endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats. Clinical Hemorheology and Microcirculation 35: 359–366.PubMedGoogle Scholar
  10. 10.
    D'Armour, F.E., and D.L. Smith. 1941. A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics 72: 74–79.Google Scholar
  11. 11.
    Abbott, F.V., K.B.J. Franklin, and F. Westbrook. 1995. The formalin test: scoring properties of first and second phases of pain response in rats. Pain 60: 91–102.PubMedCrossRefGoogle Scholar
  12. 12.
    Park, M.Y., H.J. Kwon, and M.K. Sung. 2011. Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. Life Sciences 88: 486–492.PubMedCrossRefGoogle Scholar
  13. 13.
    Halder, S., A.K. Mehta, and P.K. Mediratta. 2012. Augmented humoral immune response and decreased cell mediated immunity by Aloe vera in rats. Inflammopharmacology. Epub ahead of print.Google Scholar
  14. 14.
    Park, M.Y., H.J. Kwon, and M.K. Sung. 2009. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Bioscience, Biotechnology, and Biochemistry 73: 828–832.PubMedCrossRefGoogle Scholar
  15. 15.
    Vazquez, B., G. Avila, D. Segura, and B. Escalante. 1996. Antiinflammatory activity of extracts from Aloe vera gel. Journal of Ethnopharmacology 55: 69–75.PubMedCrossRefGoogle Scholar
  16. 16.
    Udupa, A.L., and S.L. Udupa. 1996. Analgesic activity of Aegle marmelos and Aloe vera in mice. Indian Journal of Pharmacology 36: 74.Google Scholar
  17. 17.
    Cai, Y., M. Sun, J. Xing, and H. Corke. 2004. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. Journal of Agricultural and Food Chemistry 52: 7884–7890.PubMedCrossRefGoogle Scholar
  18. 18.
    Matsuda, H., T. Morikawa, I. Toguchida, J.Y. Park, S. Harima, and M. Yoshikawa. 2001. Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. Bioorganic & Medicinal Chemistry 9: 41–50.CrossRefGoogle Scholar
  19. 19.
    Lee, H.Z., S.L. Hsu, M.C. Liu, and C.H. Wu. 2001. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. European Journal of Pharmacology 431: 287–295.PubMedCrossRefGoogle Scholar
  20. 20.
    Kuo, P.L., T.C. Lin, and C.C. Lin. 2002. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sciences 71: 1879–1892.PubMedCrossRefGoogle Scholar
  21. 21.
    Lin, J.G., G.W. Chen, T.M. Li, S.T. Chouh, T.W. Tan, and J.G. Chung. 2006. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. Journal of Urology 175: 343–347.PubMedCrossRefGoogle Scholar
  22. 22.
    Chen, H.C., W.T. Hsieh, W.C. Chang, and J.G. Chung. 2004. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food and Chemical Toxicology 42: 1251–1257.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Naveen Rathor
    • 1
  • Ashish K. Mehta
    • 2
  • Amit K. Sharma
    • 1
  • Pramod K. Mediratta
    • 1
    Email author
  • Krishna K. Sharma
    • 1
  1. 1.Department of PharmacologyUniversity College of Medical Sciences (University of Delhi)DelhiIndia
  2. 2.Department of PhysiologyUniversity College of Medical SciencesDelhiIndia

Personalised recommendations