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The Efficiency of Proanthocyanidin in an Experimental Pulmonary Fibrosis Model: Comparison with Taurine

Inflammation volume 35, pages 1402–1410 (2012)Cite this article

Abstract

Pulmonary fibrosis (PF) is a progressive fatal disorder. Bleomycin (BLM) is a widely used chemotherapeutic agent causing PF. Numerous agents have been investigated to prevent the progression of PF so far, but there is still a need to find more efficacious agents. Proanthocyanidin (PA) is a strong antioxidant, the main ingredient of grape seed extract. Since PA is ready for use in practice, we aimed to compare the preventive effect of PA in comparison with taurine (Tau) in BLM-induced PF. Forty Wistar male albino rats were used in the study and were divided into four groups: group 1, control; group 2, BLM-induced PF group; group 3, BLM-induced PF and treated with PA group; and group 4, BLM-induced PF and treated with Tau group. Treatments were begun 10 days before and continued 21 days after BLM injection. PA and Tau effectively inhibited inflammation, edema, severity of fibrosis, fibrosis extension, inflammatory cell accumulation, iNOS staining, and hydroxyproline level as well (p < 0.05). Total histological scores of the PA group were similar to the control group; Tau was significantly higher than the control group but lower than the BLM group (p < 0.05). We believe that PA could be a new treatment choice for PF, but further studies need to be conducted to verify the findings of the current study.

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ACKNOWLEDGMENTS

The authors would like to thank Patricia B. Upton for the critical reading of the manuscript.

Conflict of Interest

The authors declare that there are no conflicts of interest.

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Affiliations

  1. Department of Pathology, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Kecioren, Ankara, Turkey

    Yetkin Agackiran

  2. Department of Pharmacology, Gulhane Military Medical Academy, Ankara, Turkey

    Husamettin Gul

  3. Department of Chest Diseases, School of Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey

    Ersin Gunay

  4. Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey

    Nalan Akyurek & Leyla Memis

  5. Chest Diseases Clinic, Igdir State Hospital, Igdir, Turkey

    Sibel Gunay

  6. Department of Surgery, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey

    Yusuf Sinan Sirin

  7. Research and Developmental Institute, Gulhane Military Medical Academy, Ankara, Turkey

    Tayfun Ide

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  1. Yetkin Agackiran
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Correspondence to Ersin Gunay.

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Agackiran, Y., Gul, H., Gunay, E. et al. The Efficiency of Proanthocyanidin in an Experimental Pulmonary Fibrosis Model: Comparison with Taurine. Inflammation 35, 1402–1410 (2012). https://doi.org/10.1007/s10753-012-9453-6

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KEY WORDS

  • bleomycin
  • proanthocyanidin
  • pulmonary fibrosis
  • iNOS
  • hydroxyproline
  • inflammation