Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells

Abstract

Respiratory syncytial virus (RSV) is the most common pathogen responsible for lower respiratory diseases in children. So far, there is no effective treatment or preventative vaccine available for RSV infection, although ribavirin and dexamethasone are commonly prescribed. Resveratrol has been shown to inhibit the replication of several other viruses, thus the effect of resveratrol on RSV-induced inflammatory mediators in 9HTEo cell cultures was evaluated, and possible mechanisms of action were explored and compared with dexamethasone and ribavirin. Incubation with resveratrol resulted in decreased IL-6 production and partial inhibition of RSV replication. Resveratrol treatment also inhibited virus-induced TIR-domain-containing adapter-inducing interferon-β (TRIF) and TANK binding kinase 1 (TBK1) protein expression. These data demonstrate the ability of resveratrol to inhibit cytokine production by RSV in airway epithelial cells, indicating that it might be a therapeutic agent with both anti-inflammatory and antiviral potential for the treatment of RSV infection.

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ACKNOWLEDGMENTS

This study was supported by the Program for New Century Excellent Talents in University (06-775), the Key program of Chongqing Medical University, and Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20105503120003)

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Correspondence to En-mei Liu.

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Xie, X., Zang, N., Li, S. et al. Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells. Inflammation 35, 1392–1401 (2012). https://doi.org/10.1007/s10753-012-9452-7

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KEY WORDS

  • resveratrol
  • respiratory syncytial virus
  • toll-like receptor
  • inflammation
  • airway epithelial cell