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Adiponectin and Metabolic Syndrome in a Tunisian Population

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Abstract

The aim of this study was to investigate the relationship between the adiponectin levels and various characteristics of the metabolic syndrome (MS) in a sample of the Tunisian population. Three hundred and fifty-four individuals were included in this study. Body mass index, blood pressure, HDL-cholesterol, triglycerides, glucose, insulin, and adiponectin concentrations were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). MS was identified with the NCEP-ATP III criteria. Subjects with MS showed significantly lower adiponectin levels compared to those without MS. For both genders, the prevalence and the number of MS components increased significantly as the adiponectin concentrations decreased. Subjects with the lowest adiponectin quartile had an increased risk of MS adjusted for age, gender, and HOMA-IR. Our findings suggest that hypoadiponectinemia is strongly associated with the risk of MS independent of insulin resistance.

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Acknowledgments

This work was supported by a grant from “The Ministry of Higher Education, Scientific Research and Technology” of Tunisia.

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Authors and Affiliations

  1. Research Laboratory LR99ES11, Biochemistry Department, Rabta University Hospital, Jabbari, Tunis, 1007, Tunisia

    Samir Ben Ali, Riadh Jemaa, Amani Kallel, Moncef Feki & Naziha Kaabachi

  2. Endocrinology Department, Rabta University Hospital, Jabbari, Tunis, 1007, Tunisia

    Bouchra Ftouhi & Hedia Slimene

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  1. Samir Ben Ali
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  2. Riadh Jemaa
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Correspondence to Samir Ben Ali.

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Ben Ali, S., Jemaa, R., Ftouhi, B. et al. Adiponectin and Metabolic Syndrome in a Tunisian Population. Inflammation 35, 828–833 (2012). https://doi.org/10.1007/s10753-011-9383-8

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