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Gender-related Distribution of the Interleukin-1β and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients with End-stage Liver Disease

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Abstract

Interleukin-1β (IL-1β) genetic polymorphisms and IL-1 receptor antagonist (IL1RN) variable number tandem repeat (VNTR) seem to be related with the occurrence of chronic diseases. This study aimed to verify whether IL-1β -511>C/T, -31>T/C, +3953>C/T and IL1RN VNTR were associated to the development of liver cirrhosis. Two hundred forty cirrhotic patients were involved in the study. A significant trend was detected, for increasing cirrhosis frequencies, grouping the patients as follows: females and males carrying neither the IL-1β (-511 -31) T-C/T-C or T-C/(T-T or C-C) diplotypes nor any IL1RN A2 allele (138/292), males carrying either the IL-1β T-C/T-C or T-C/(T-T or C-C) diplotypes or at least one IL1RN A2 allele (74/147) and males carrying either the IL-1β T-C/T-C or T-C/(T-T or C-C) diplotypes and at least one IL1RN A2 allele (28/37) (p < 0.01). IL-1β polymorphisms are associated with the occurrence of end stage liver disease. IL-1β inflammatory activity appears more pronounced in males.

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Acknowledgements

Supported in part by grants from the “Ricerca Sanitaria Finalizzata” Program, Regione Piemonte, Italy and Fondazione CRUP Udine, Italy

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Authors and Affiliations

  1. Laboratory Medicine, University of Udine, Piazzale S. M. della Misericordia 1, 33100, Udine, Italy

    Elisabetta Fontanini, Annarosa Cussigh, Edmondo Falleti & Sara Cmet

  2. Medical Liver Transplantation Unit, Internal Medicine, DPMSC, University of Udine, Piazzale S. M. della Misericordia 1, 33100, Udine, Italy

    Carlo Fabris, Pierluigi Toniutto, Davide Bitetto, Elisa Fumolo, Ezio Fornasiere & Sara Bignulin

  3. Department of Clinical & Experimental Medicine, University of Eastern Piedmont “A. Avogadro”, Novara, Italy

    David J. Pinato, Rosalba Minisini & Mario Pirisi

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  1. Elisabetta Fontanini
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  2. Annarosa Cussigh
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  3. Carlo Fabris
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Correspondence to Pierluigi Toniutto.

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Fontanini, E., Cussigh, A., Fabris, C. et al. Gender-related Distribution of the Interleukin-1β and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients with End-stage Liver Disease. Inflammation 33, 251–258 (2010). https://doi.org/10.1007/s10753-009-9179-2

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  • DOI: https://doi.org/10.1007/s10753-009-9179-2

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