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Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats

Inflammation volume 32, pages 37–46 (2009)Cite this article

Abstract

To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic score, elevated DNA fragmentation and chemiluminescence levels of the saline-treated ulcer groups were all reduced by ALA treatment. Likewise, ALA treatment inhibited chemiluminescence levels in both early and late ulcer groups. Marked reduction in glutathione levels of the saline-treated early ulcer group was reversed by ALA treatment, while ALA treatment was effective in depressing gastric myeloperoxidase activity in the late ulcer group. In conclusion, ALA treatment shows protective role in the healing of acetic acid-induced gastric injury in rats via the suppression of neutrophil accumulation, preservation of endogenous glutathione, inhibition of reactive oxidant generation and apoptosis.

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Acknowledgments

The study was presented at Digestive Disease Week 2008 and published in abstract from in Gastroenterology 2008;134(4): A239.

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Affiliations

  1. Physiology, Health Sciences Faculty, Department of Nursing, Marmara University, Haydarpaşa, 34668, İstanbul, Turkey

    Berna Karakoyun

  2. Vocational School of Health Related Professions, Department of Medical Laboratory, Marmara University, Istanbul, Turkey

    Meral Yüksel

  3. School of Medicine, Department of Histology and Embryology, Marmara University, Istanbul, Turkey

    Feriha Ercan

  4. School of Medicine, Department of Medical Biology, Marmara University, Istanbul, Turkey

    Can Erzik

  5. School of Medicine, Department of Physiology, Marmara University, Istanbul, Turkey

    Berrak Ç. Yeğen

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  1. Berna Karakoyun
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  2. Meral Yüksel
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Correspondence to Berna Karakoyun.

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Karakoyun, B., Yüksel, M., Ercan, F. et al. Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats. Inflammation 32, 37–46 (2009). https://doi.org/10.1007/s10753-008-9100-4

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KEY WORDS

  • alpha-lipoic acid
  • ulcer healing
  • acetic acid
  • oxidant damage
  • apoptosis