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Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

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Abstract

Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis + saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis + CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.

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Acknowledgement

The authors thank Dr. Fatih Kara for his excellent help in reviewing our statistical analysis.

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Authors and Affiliations

  1. Meram Medical Faculty, Department of General Surgery, Selcuk University, Konya, Turkey

    Ahmet Tekin, Tevfik Küçükkartallar & Adil Kartal

  2. Medical Faculty, Department of General Surgery, Akdeniz University, Antalya, Turkey

    Serdar Türkyılmaz

  3. Medical Faculty, Department of General Surgery, Karadeniz Technical University, Trabzon, Turkey

    Ayhan Dinckan

  4. Meram Medical Faculty, Department of Pathology, Selcuk University, Konya, Turkey

    Hasan Esen

  5. Department of Chemistry, Inonu University, Malatya, Turkey

    Burhan Ateş

  6. Department of General Surgery, Private Konya Hospital, Konya, Turkey

    Hüseyin Yılmaz

  7. Feritpaşa mah. Gökhan Sok. Mehmet Katırcı Apt, C Blok. 11/13, 42060, Selçuklu, Konya, Turkey

    Ahmet Tekin

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  1. Ahmet Tekin
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Correspondence to Ahmet Tekin.

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Tekin, A., Küçükkartallar, T., Türkyılmaz, S. et al. Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats. Inflammation 31, 273–280 (2008). https://doi.org/10.1007/s10753-008-9075-1

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