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The Effects of Anti-Adhesion Materials in Preventing Postoperative Adhesion in Abdominal Cavity (Anti-Adhesion Materials for Postoperative Adhesions)

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Abstract

Purpose

The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.

Materials and Methods

Rats were assigned to five groups: Group 1: Control. Group 2: chitin layers were used. Group 3: Na-hyaluronate / carboxymethylcellulose layers were used. Group 4: Na-hyaluronate gel was poured into the abdomen. Group 5: methylprednisolone was injected. The adhesion frequency and grade were scored according to Granat. Blood was taken for Hb, AST, BUN and albumin levels determination.

Findings

The adhesion frequencies (right and left) and grades were as follow in Groups; I: 82%, 91%, 2.63 ± 1.22; II: 8.3%, 25%, 0.58 ± 0.66; III: 17%, 33%, 1.08 ± 1.08; IV: 50%, 58%, 1.41 ± 1.44; V: 50%, 42%, 1.41 ± 1.50. The adhesion phase in all study groups was found significantly low compared to control group, p < 0.05. No difference was observed among serologic and hematological parameters in all groups.

Conclusion

All the materials used significantly lowered the adhesion frequency and grade.

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Authors and Affiliations

  1. Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey

    Mustafa Sahin, Murat Cakir, Ahmet Tekin & Tevfik Kucukkartallar

  2. Department of Surgical Emergency Service, Ankara Numune Training and Research Hospital, Ankara, Turkey

    Fatih Mehmet Avsar

  3. Department of Biochemistry, Selcuk University Meram Medical Faculty, Konya, Turkey

    Mehmet Akoz

  4. Feritpaşa mah. Gökhan Sok. Mehmet Katirci Apt. C Blok. 11/13, 42060 Selçuklu, Konya, Turkey

    Ahmet Tekin

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  1. Mustafa Sahin
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  2. Murat Cakir
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  3. Fatih Mehmet Avsar
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Correspondence to Ahmet Tekin.

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Sahin, M., Cakir, M., Avsar, F.M. et al. The Effects of Anti-Adhesion Materials in Preventing Postoperative Adhesion in Abdominal Cavity (Anti-Adhesion Materials for Postoperative Adhesions). Inflammation 30, 244–249 (2007). https://doi.org/10.1007/s10753-007-9043-1

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  • DOI: https://doi.org/10.1007/s10753-007-9043-1

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