Abstract
Packed red blood cells (RBC) are main blood components used in transfusiology. During storage, preserved blood cells undergo progressive structural and functional changes that may reduce red-cell function and viability after transfusion. As the hemoglobin is the main and active component of erythrocytes, we consider that oxidized hemoglobin derivatives formation cause those changes. With the aim of developing the new criteria for donated blood suitability for transfusion, we studied storage-related changes in red blood cells hemoglobin by means of analytical fitting of Mössbauer spectra. We analyzed Mössbauer spectra of set RBC’s samples from volunteer donors every few days during their storage. Using those data, we built kinetic curves of various hemoglobin derivatives changes during RBC storage for different hemoglobin forms concentration in RBC samples. We found that kinetic curves are specific for each donor. They also depend on the donor’s age and health condition at the time of donation. Based on our spectroscopy results we suggested an objective criteria for duration of storage of regular donors RBC.
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Acknowledgments
The authors are grateful to donor volonteers, Moscow Government Departament of Health, Gematology scintific center of Russian Academy of Science and Moscow State University Program of Development.
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This article is part of the Topical Collection on Proceedings of the International Conference on the Applications of the Mössbauer Effect (ICAME 2017), Saint-Petersburg, Russia, 3-8 September 2017
Edited by Valentin Semenov
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A., N.A., Yu., K.T. & M., K.S. Mossbauer study of different factors influence on donated blood quality. Hyperfine Interact 239, 19 (2018). https://doi.org/10.1007/s10751-017-1482-y
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DOI: https://doi.org/10.1007/s10751-017-1482-y