Skip to main content
SpringerLink
Log in

Using Mössbauer spectroscopy as key technique in the investigation of nanosized magnetic particles for drug delivery

  • Published:
Hyperfine Interactions Aims and scope Submit manuscript

Abstract

This paper describes how cobalt ferrite nanoparticles, suspended as ionic or biocompatible magnetic fluids, can be used as a platform to built complex nanosized magnetic materials, more specifically magnetic drug delivery systems. In particular, the paper is addressed to the discussion of the use of the Mössbauer spectroscopy as an extremely useful technique in supporting the investigation of key aspects related to the properties of the hosted magnetic nanosized particle. Example of the use of the Mössbauer spectroscopy in accessing information regarding the nanoparticle modification due to the empirical process which provides long term chemical stability is included in the paper.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Pardoe, H., Chua-anusorn, W., St Pierre, T.G.: J. Magn. Magn. Mater. 225, 41 (2001)

    Article  ADS  Google Scholar 

  2. Rabelo, D., Lima, E.C.D., Reis, A.C., Nunes, W.C., Novak, M.A., Morais, P.C.: Nano Lett. 1, 105 (2001)

    Article  Google Scholar 

  3. Mikhaylova, M., Jo, Y.S., Kim, D.K., Bobrysheva, N., Anderson, Y., Eriksson, T., Osmolowsky, M., Semenov, V., Muhammed, M.: Hyperfine Interact 156/157, 257 (2004)

    Article  ADS  Google Scholar 

  4. Garg, V.K., Oliveira, A.C., Wagener, M., Buske, N., Morais, P.C.: J. Magn. Magn. Mater. 272/276, 2326 (2004)

    Article  ADS  Google Scholar 

  5. Sinha, A., Nayar, S., Nath, B.K., Das, D., Mukhopadhyay, P.K.: Colloids Surf., B Biointerfaces 43, 7 (2005)

    Article  Google Scholar 

  6. Arelaro, A.D., Brandl, A.L., Lima, E. Jr., Gamarra, L.F., Brito, G.E.S., Pontuschka, W.M., Goya, G.F.: J. Appl. Phys. 97, 10J316 (2005)

    Article  Google Scholar 

  7. Prasad, N.K., Panda, D., Singh, S., Mukadam, M.D., Yusuf, S.M., Bahadur, D.: J. Appl. Phys. 97, 10Q903 (2005)

    Article  Google Scholar 

  8. Soler, M.A.G., da Silva, S.W., Garg, V.K., Oliveira, A.C., Azevedo, R.B., Pimenta, A.C.M., Lima, E.C.D., Morais, P.C.: Surf. Sci. 575, 12 (2005)

    Article  ADS  Google Scholar 

  9. Nakagomi, F., da Silva, S.W., Garg, V.K., Oliveira, A.C., Morais, P.C., Franco, A. Jr., Lima, E.C.D.: J. Appl. Phys. 101, 09M514 (2007)

    Article  Google Scholar 

  10. Soler, M.A.G., Lima, E.C.D., da Silva, S.W., Melo, T.F.O., Pimenta, A.C.M., Sinnecker, J.P., Azevedo, R.B., Garg, V.K., Oliveira, A.C., Novak, M.A., Morais, P.C.: Langmuir 23, 9611 (2007)

    Article  Google Scholar 

  11. Sjogren, C.E., Johansson, C., Naevestad, A., Sontum, P.C., Briley-Saebo, K., Fahlvik, A.K.: Magn. Res. Imaging 15, 55 (1997)

    Article  Google Scholar 

  12. Lacava, B.M., Azevedo, R.B., Silva, L.P., Lacava, Z.G.M., Skeff Neto, K., Buske, N., Bakuzis, A.F., Morais, P.C.: Appl. Phys. Lett. 77, 1876 (2000)

    Article  ADS  Google Scholar 

  13. Morais, P.C., Azevedo, R.B., Silva, L.P., Rabelo, D., Lima, E.C.D.: Phys. Stat. Sol. (a) 187, 203 (2001)

    Article  ADS  Google Scholar 

  14. Kim, D.K., Mikhaylova, M., Zhang, Y., Muhammed, M.: Chem. Mater. 15, 1617 (2003)

    Article  Google Scholar 

  15. Mikhaylova, M., Kim, D.K., Bobrysheva, N., Osmolowsky, M., Semenov, V., Tsakalados, T., Muhammed, M.: Langmuir 20, 2472 (2004)

    Article  Google Scholar 

  16. de Menezes, A.S., Remédios, C.M.R., Sasaki, J.M., da Silva, L.R.D., Goes, J.C., Jardim, P.M., Miranda, M.A.R.: J. Non-Cryst. Solids 353, 1091 (2007)

    Article  ADS  Google Scholar 

  17. Klokkenburg, M., Erne, B.H., Meeldijk, J.D., Wiedenmann, A., Petukhov, A.V., Dullens, R.P.A., Philipse, A.P.: Phys. Rev. Lett. 97, 185702 (2006)

    Article  ADS  Google Scholar 

  18. Allen, P.D., St Pierre, T.G., Chua-anusorn, W., Strom, V., Rao, K.V.: Biochim. Biophys. Acta. 1500, 186 (2000)

    Google Scholar 

  19. Morais, P.C., Lacava, B.M., Bakuzis, A.F., Lacava, L.M., Silva, L.P., Azevedo, R.B., Lacava, Z.G.M., Buske, N., Nunes, W.C., Novak, M.A.: J. Magn. Magn. Mater. 226, 1899 (2001)

    Article  ADS  Google Scholar 

  20. Rodriguez, A.F.R., Oliveira, A.C., Morais, P.C., Rabelo, D., Lima, E.C.D.: J. Appl. Phys. 93, 6963 (2003)

    Article  ADS  Google Scholar 

  21. Tartaj, P., Gonzalez-Carreno, T., Bomati-Miguel, O., Serna, C.J., Bonville, P.: Phys. Rev. B 69, 094401 (2004)

    Article  ADS  Google Scholar 

  22. Scholten, P.: IEEE Trans. Magn. 16, 221 (1980)

    Article  ADS  Google Scholar 

  23. Xu, M., Ridler, P.J.: J. Appl. Phys. 82, 326 (1997)

    Article  ADS  Google Scholar 

  24. Morais, P.C., Gravina, P.P., Skeff Neto, K., Lacava, B.M.: Thin Solid Films 515, 226 (2005)

    Article  ADS  Google Scholar 

  25. Oliveira, F.M.L., Avelino, S.R., Eloi, M.T.A., Gravina, P.P., Skeff Neto, K., Lima, E.C.D., Morais, P.C.: J. Non-Cryst. Solids 352, 3689 (2006)

    Article  ADS  Google Scholar 

  26. Morais, P.C., Silveira, L.B., Santos, J.G., Oliveira, A.C., Tronconi, A.L., Santos, R.L., Lima, E.C.D., Marchetti, J.M., Tedesco, A.C.: IEEE Trans. Magn. 41, 3382 (2005)

    Article  ADS  Google Scholar 

  27. Avelino, S.R., Oliveira, F.M.L., Oliveira, A.C., Morais, P.C.: J. Non-Cryst. Solids 352, 3692 (2006)

    Article  ADS  Google Scholar 

  28. da Silva, S.W., Pedroza, R.C., Sartoratto, P.P.C., Rezende, D.R., da Silva Neto, A.V., Soler, M.A.G., Morais, P.C.: J. Non-Cryst. Solids 352, 1602 (2006)

    Article  ADS  Google Scholar 

  29. Sartoratto, P.P.C., Caiado, K.L., Pedroza, R.C., da Silva, S.W., Morais, P.C.: J. Alloy Compd. 434/435, 650 (2007)

    Article  Google Scholar 

  30. Morais, P.C., Santos, J.G., Skeff Neto, K., Pelegrini, F., De Cuyper, M.: J. Magn. Magn. Mater. 293, 526 (2005)

    Article  ADS  Google Scholar 

  31. Sadeghiani, N., Barbosa, L.S., Guedes, M.H.A., Chaves, S.B., Santos, J.G., Silva, O., Pelegrini, F., Azevedo, R.B., Morais, P.C., Lacava, Z.G.M.: IEEE Trans. Magn. 41, 4108 (2005)

    Article  ADS  Google Scholar 

  32. Pereira, A.R., Miranda, K.L.C., Sartoratto, P.P.C., Morais, P.C., Bakuzis, A.F.: J. Appl. Phys. 100, 086110 (2006)

    Article  ADS  Google Scholar 

  33. Godoy Morais, J.P., Azevedo, R.B., Silva, L.P., Lacava, Z.G.M., Bao, S.N., Silva, O., Pelegrini, F., Gansau, C., Buske, N., Safarik, I., Safarikova, M., Morais, P.C.: J. Magn. Magn. Mater. 272/276, 2400 (2004)

    Article  ADS  Google Scholar 

  34. Silva, L.P., Kuchelhaus, S., Guedes, M.H.A., Lacava, Z.G.M., Tedesco, A.C., Morais, P.C., Azevedo, R.B.: J. Magn. Magn. Mater. 289, 463 (2005)

    Article  ADS  Google Scholar 

  35. Lacava, Z.G.M., Lacava, L.M., Fonseca, M.J.P., Souza, T.M.M., Pereira, L.O., Silva, O., Pelegrini, F., Sabolovic, D., Sestier, C., Azevedo, R.B., Buske, N., Morais, P.C.: IEEE Trans. Magn. 42, 3599 (2006)

    Article  ADS  Google Scholar 

  36. Macaroff, P.P., Oliveira, D.M., Lacava, Z.G.M., Lima, E.C.D., Morais, P.C., Tedesco, A.C.: J. Appl. Phys. 97, 10Q906 (2005)

    Article  Google Scholar 

  37. Macaroff, P.P., Oliveira, D.M., Ribeiro, K.F., Tedesco, A.C., Lacava, Z.G.M., Lima, E.C.D., Morais, P.C.: IEEE Trans. Magn. 41, 4105 (2005)

    Article  ADS  Google Scholar 

  38. Oliveira, D.M., Lacava, Z.G.M., Lima, E.C.D., Morais, P.C., Tedesco, A.C.: J. Nanosci. Nanotechnol. 6, 2432 (2006)

    Article  Google Scholar 

  39. Macaroff, P.P., Primo, F.L., Azevedo, R.B., Lacava, Z.G.M., Morais, P.C., Tedesco, A.C.: IEEE Trans. Magn. 42, 3596 (2006)

    Article  ADS  Google Scholar 

  40. Primo, F.L., Michieleto, L., Rodrigues, M.M.A., Macaroff, P.P., Morais, P.C., Lacava, Z.G.M., Bentley, M.V.L.B., Tedesco, A.C.: J. Magn. Magn. Mater. 311, 354 (2007)

    Article  ADS  Google Scholar 

  41. Calderwood, S.K., Asea, A.: Int. Hyperthermia 18, 597 (2002)

    Article  Google Scholar 

  42. Guedes, M.H.A., Guedes, M.E.A., Morais, P.C., da Silva, M.F., Santos, T.S., Alves, J.P. Jr., Bertelli, C.E., Azevedo, R.B., Lacava, Z.G.M.: J. Magn. Magn. Mater. 272/276, 2406 (2004)

    Article  ADS  Google Scholar 

  43. Guedes, M.H.A., Sadeghiani, N., Peixoto, D.L.G., Coelho, J.P., Barbosa, L.S., Azevedo, R.B., Kuckelhaus, S., da Silva, M.F., Morais, P.C., Lacava, Z.G.M.: J. Magn. Magn. Mater. 293, 283 (2005)

    Article  ADS  Google Scholar 

  44. Simioni, A.R., Primo, F.L., Rodrigues, M.A., Lacava, Z.G.M., Morais, P.C., Tedesco, A.C.: IEEE Trans. Magn. 43, 2459 (2007)

    Article  ADS  Google Scholar 

  45. Massart, R.: IEEE Trans. Magn. 17, 1247 (1981)

    Article  ADS  Google Scholar 

  46. Tourinho, F., Franck, R., Massart, R.: J. Mater. Sci. 25, 3249 (1990)

    Article  Google Scholar 

  47. Morais, P.C., Garg, V.K., Oliveira, A.C., Silva, L.P., Azevedo, R.B., Silva, A.M.L., Lima, E.C.D.: J. Magn. Magn. Mater. 225, 37 (2001)

    Article  ADS  Google Scholar 

  48. Muller, R., Hiergeist, R., Steinmetz, H., Ayoub, N., Fujisaki, M., Schuppel, W.: J. Magn. Magn. Mater. 201, 34 (1999)

    Article  ADS  Google Scholar 

  49. Goossens, A., de Jongh, L.J., Butter, K., Philipse, A.P., Craje, M.W.J., van der Kraan, A.M.: Hyperfine Interact. 141, 381 (2002)

    Article  ADS  Google Scholar 

  50. Sartoratto, P.P.C., Neto, A.V.S., Lima, E.C.D., Rodrigues de Sa, A.L.C., Morais, P.C.: J. Appl. Phys. 97, 10Q917 (2005)

    Article  Google Scholar 

  51. Gotze, T., Gansau, C., Buske, N., Roeder, M., Görnert, P., Bahr, M.: J. Magn. Magn. Mater. 252, 399 (2002)

    Article  ADS  Google Scholar 

  52. Morais, P.C., Santos, R.L., Pimenta, A.C.M., Azevedo, R.B., Lima, E.C.D.: Thin Solid Films 515, 266 (2006)

    Article  ADS  Google Scholar 

  53. Rocha, F.M., Pinho, S.C., Zollner, R.L., Santana, M.H.A.: J. Magn. Magn. Mater. 225, 101 (2001)

    Article  ADS  Google Scholar 

  54. De Cuyper, M., Valtonen, S.: J. Magn. Magn. Mater. 225, 89 (2001)

    Article  ADS  Google Scholar 

  55. Hodenius, M., De Cuyper, M., Desender, L., Muller-Schulte, D., Steigel, A., Lueken, H.: Chem. Phys. Lipids 120, 75 (2002)

    Article  Google Scholar 

  56. De Cuyper, M., Hodenius, M., Lacava, Z.G.M., Azevedo, R.B., da Silva, M.F., Morais, P.C., Santana, M.H.A.: J. Colloid Interface Sci. 245, 274 (2002)

    Article  Google Scholar 

  57. De Cuyper, M., Muller, P., Lueken, H., Hodenius, M.: J. Phys. Cond. Matter. 15, S1425 (2003)

    Article  Google Scholar 

  58. Giri, J., Thakurta, S.G., Bellare, J., Nigam, A.K., Bahadur, D.: J. Magn. Magn. Mater. 293, 62 (2005)

    Article  ADS  Google Scholar 

  59. Chen, K.Z., Luo, W.L., Rahman, Z.U., Guo, Y., Schulte, A.: J. Dipersion Sci. Technol. 28, 471 (2007)

    Article  Google Scholar 

  60. Solans, C., Izquierdo, P., Nolla, J., Azemar, N., Garcia-Celma, M.J.: Cur. Op. Colloid Interface Sci. 10, 102 (2005)

    Article  Google Scholar 

  61. Yu, C.H., Tam, K.Y., Lo, C.C.H., Tsang, S.C.: IEEE Trans. Magn. 43, 2436 (2007)

    Article  ADS  Google Scholar 

  62. Masuda, M., Maeda, K., Kobayashi, T., Shiomi, S., Fujiwara, Y., Saito, Y.: Jpn. J. Appl. Phys. 39, L733 (2000)

    Article  ADS  Google Scholar 

  63. Chen, C.P., Chang, T.H., Wang, T.F.: Ceram. Int. 28, 925 (2002)

    Article  Google Scholar 

  64. Geng, D.Y., Zhang, Z.D., Zhang, W.S., Si, P.Z., Zhao, X.G., Liu, W., Hu, Z.X., Song, X.P.: Scripta Mater. 48, 593 (2003)

    Article  Google Scholar 

  65. Erokhina, S., Berzina, T., Cristofolini, L., Shchukin, D., Sukhorukov, G., Musa, L., Erokhin, V., Fontana, M.P.: J. Magn. Magn. Mater. 272/276, 1353 (2004)

    Article  ADS  Google Scholar 

  66. Sukhorukov, G.B., Mohwald, H.: Trends Biotechnol. 25, 93 (2007)

    Article  Google Scholar 

  67. Baroli, B., López-Quintela, M.A., Delgado-Charro, M.B., Fadda, A.M., Blanco-Mendez, J.: J. Control. Release 69, 209 (2000)

    Article  Google Scholar 

  68. Fanyao, Q., Morais, P.C.: J. Phys. Chem. B 104, 5232 (2000)

    Article  Google Scholar 

  69. Vestal, C.R., Zhang, Z.J.: J. Am. Chem. Soc. 125, 9828 (2003)

    Article  Google Scholar 

  70. Kuchelhaus, S., Tedesco, A.C., Oliveira, D.M., Morais, P.C., Boaventura, G.R., Lacava, Z.G.M.: J. Appl. Phys. 97, 10Q910 (2005)

    Article  Google Scholar 

  71. Choi, E.J., Ahn, Y., Kim, S., Hyun An, D., Kang, K.U., Lee, B., Baek, K.S., Oak, H.N.: J. Magn. Magn. Mater. 262, L198 (2003)

    Article  ADS  Google Scholar 

  72. Lee, D.H., Kim, J.S., Lee, J.Y., Hyun Yo, C., Kim, K.H.: Solid St. Commun. 96, 445 (1995)

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Núcleo de Física Aplicada, Instituto de Física, Universidade de Brasília, Brasília, Federal District, 70910-900, Brazil

    P. C. Morais

Authors
  1. P. C. Morais
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. C. Morais.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morais, P.C. Using Mössbauer spectroscopy as key technique in the investigation of nanosized magnetic particles for drug delivery. Hyperfine Interact 181, 1–12 (2008). https://doi.org/10.1007/s10751-008-9609-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10751-008-9609-9

Keywords

Search

Navigation