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Human Physiology

, Volume 31, Issue 5, pp 599–605 | Cite as

Increase in the Incidence of Allergy to Prosthetic Materials and Local Anesthetics: Immunophysiology and Laboratory Diagnostics of Intolerance

  • I. D. Ponyakina
  • L. G. Sagan
  • K. A. Lebedev
Article
  • 28 Downloads

Abstract

Combined analysis of drug sensitivity in vitro and in vivo is necessary for reliable diagnosis of the intolerance to prosthetic materials and local anesthetics as an intrinsic allergic reaction, especially in the cases of generally weak allergic reactions. Changes in peroxidase release from granulocytes in response to a corresponding substance is an effective in vitro test, and the provocative mucosal-gingival test (MGT) is used in vivo. During the past decade, a growth was observed in the population developing allergies to prosthetic materials and local anesthetics, which is expressed in an increased number of patients with intolerance to these materials against the background of increasing hyperresponsiveness to the drugs which have usually been tolerated well, as well as an increased proportion of patients with a polyvalent allergy to many prosthetic materials and anesthetics. At the same time, the amount of weak responses to drugs in the in vitro test has increased. Some of these patients exhibit a pathologic response to the given drug, which can be detected using the MGT. In most cases, polyvalent allergies to prosthetic materials or anesthetics and a pathological response accompanied by a weak in vitro reaction are found in patients with bronchial asthma and other chronic allergies, chronic candidosis of the oral cavity, and chronic Helicobacter and Giardia lamblia infections.

Keywords

Asthma Human Physiology Local Anesthetic Allergic Reaction Oral Cavity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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REFERENCES

  1. 1.
    Sabroe, J., Read, R.S., Whyte, M.K.B., et al., Toll-like Receptors in Health and Disese: Complex Question Remain, J. Immunol., 2003, vol. 15, no.171, p. 1630.Google Scholar
  2. 2.
    Luss, L.V., Allergy and Intrinsic Allergy in Clinic, in Sovremennye problemy allergologii, klinicheskoi immunologii i immunofarmakologii (Current Problems in Allergology, Clinical Immunology, and Immunopharmacology), Moscow, 1998, p. 45.Google Scholar
  3. 3.
    Reshetnikova, D.I., Fassakhov, R.S., Nizamov, I.G., et al., The Place of Acute Allergic Reactions in the Structure of Calls for Urgent Medical Care, Allergologiya, 2000, no. 4, p. 3.Google Scholar
  4. 4.
    Watkins, J., and Levi, S.D., Reaktsii nemedlennogo tipa pri anestezii (Early Reactions in Anesthesia), Moscow: Meditsina, 1991.Google Scholar
  5. 5.
    Pytskii, V.I., Andrianova, N.V., and Artomasova, A.V., Allergicheskie zabolevaniya (Allergic Diseases), Moscow: Triada-X, 1999.Google Scholar
  6. 6.
    Renn, C.N., Dorfmueller, F., and Merk, H.F., Unvertraglichkeit von Implantaten-Herausforderung fur die Allergologie, H + G, 2002, vol. 77, no.5, p. 230.Google Scholar
  7. 7.
    Peter, T., Burkhard, P., and Bernhard, P., Reaktionen aut Metallimplantate, Dtsch. Arztebl., 2001, vol. 98, no.30, p. 1580.Google Scholar
  8. 8.
    Patterson, R., Gremmer, L.K., and Grinberg, P.A., Allergicheskie bolezni (diagnostika i lechenie) (Allergic Diseases: Diagnosis and Treatment), Moscow: GEOTAR Meditsina, 2000.Google Scholar
  9. 9.
    Novikov, V.K., Sergeev, Yu.V., and Novikov, P.D., Lekarstvennaya allergiya (Drug Allergy), Moscow: Natsional'naya Akademiya Mikologii, 2001.Google Scholar
  10. 10.
    Markov, B.P. and Dzhirikov, Yu.A., Prevention of the Intolerance of Metal Implants in the Oral Cavity, Stomatologiya, 1995, no. 11, p. 52.Google Scholar
  11. 11.
    Doinikov, A.I., Kortyakov, E.M., Dolgin, and Dolgin, E.M., Biosovmestimost' splavov, primenyaemykh v ortodonticheskoi stomatologii (Biological Compatibility of Alloys Used in Orthodontics), Moscow: MMSI, 1986.Google Scholar
  12. 12.
    Gozhaya, L.D., Allergicheskie zabolevaniya v ortopedicheskoi stomatologii (Allergic Diseases in Orthopedics), Moscow, 1988.Google Scholar
  13. 13.
    Merk, H.F., Allergische Kran Kheistbilder—Arzneimitte breaktionen, Dtsch. Arztebl., 2000, vol. 97, no.45, p. 2264.Google Scholar
  14. 14.
    Gushchin, I.S., Cellular and Molecular Organization of Allergic Inflammation, in Bronkhial'naya astma (Bronchial Asthma), Moscow: Agar, 1997, vol. 1, p. 431.Google Scholar
  15. 15.
    Ponyakina, I.D., Strokina, O.M., Mitronin, A.V., et al., Detection of Enhanced Sensitivity to Dental Drugs in Vitro, Stomatol. Vsekh, 2004, no. 3, p. 44.Google Scholar
  16. 16.
    Evsyukova, E.V. and Fedoseev, G.B., The Role of Arachidonic Acid Metabolites in the Mechanisms of Allergic Reactions, Allergologiya, 2000, no. 4, p. 21.Google Scholar
  17. 17.
    Nagy, L., Zec, T.H., Goetzl, L., et al., Complement Receptor Enhancement and Chemotaxis of Human Neutrophils and Eosinophils by Leukotrienes and other Lipoxygenase Products, Clin. Exp. Immunol., 1982, vol. 47, p. 541.PubMedGoogle Scholar
  18. 18.
    Sosman, J. and Busse, W., Histamine Inhibition of Neutrophil Lysosomal Enzyme Release: An H2 Histamine Receptor Source, Science, 1971, vol. 194, p. 743.Google Scholar
  19. 19.
    Stepanova, E.V., Sveranovskaya, V.V., Kuznetsova, N.M., et al., Studying the Mechanisms of Leukocyte Alteration in Patients with Intolerance of Some Drugs as Exemplified by Procaine, Zh. Mikrobiol., 2001, no. 6, p. 59.Google Scholar
  20. 20.
    Lebedev, K.A. and Sagan, L.G., An Innocuous Physiologically Normal Provocative Test for Accurate Estimation of Intolerance of Materials Used in Dentistry, Fiziol. Chel., 2002, vol. 28, no.2, p. 150.Google Scholar
  21. 21.
    Lebedev, K.A. and Ponyakina, I.D., Physiological Mechanisms of Inflammation and Atopic Allergy, Fiziol. Chel., 2000, vol. 26, no.6, p. 84.Google Scholar
  22. 22.
    Lebedev, K.A., Maksimovskii, Yu.M., Kulmagombetov, I.R., and Godunova, M.I., The Mucosal—Gingival Test for Detecting Hypersensitivity to Local Anesthetics, Maestro Stomatol., 2003, no. 3(12), p. 74.Google Scholar
  23. 23.
    Lebedev, K.A., Kulmagombetov, I.R., Kozachenko, N.V., and Godunova, M.I., Kaz. Patent 0974.11117/2, 2003.Google Scholar
  24. 24.
    Lopatin, A.S., On the Problems of Flow Drug Effect, Ter. Arkh., 1992, no. 10, p. 68.Google Scholar
  25. 25.
    Federal'noe rukovodstvo dlya vrachei po ispol'zovaniyu lekarstvennykh sredstv (Federal Guidelines for Physicians on the Use of Drugs), Chuchalin, A.G., Vyalikov, A.I., and Belousov, Yu.B., Eds., Moscow, 2001.Google Scholar
  26. 26.
    Malomed, S., Allergic and Toxic Reactions to Local Anesthetics, Klin. Stomatol., 2004, no. 4, p. 27.Google Scholar
  27. 27.
    Rostoka, D., Kroicha, Yu., Kuznetsova, V.I., et al., Adhesion of Candida albicans to Correcting Plastics Used for Dentures, Stomatologiya, 2004, no. 5, p. 14.Google Scholar
  28. 28.
    Samraya, K.E., Jones, B.M., and Scully, C., Essential Microbiology for Dentistry, Edinburg: Churchill Livingston, 2002.Google Scholar
  29. 29.
    Goryachkina, L.A. and Borzova, E.Yu., The Role of Helicobacter Infection in the Pathogenesis of Chronic Urticaria, Allergologiya, 2004, no. 1, p. 31.Google Scholar
  30. 30.
    Enright, T., The Role of a Documented Allergic Profile As Risk Factor for Radiographic Contrast Media Reactions, Ann. Allergy, 1989, vol. 62, p. 303.Google Scholar
  31. 31.
    Infektsionnye bolezni (Infectious Diseases), Pokrovskii, V.I., Ed., Moscow: Meditsina, 1996.Google Scholar
  32. 32.
    Tsepov, L.M. and Nikolaev, A.I., Diagnostika i lechenie zabolevanii parodonta (Diagnosis and Treatment of Diseases of the Parodontium), Moscow: MEDpress-Inform, 2002.Google Scholar
  33. 33.
    Lebedev, K.A., Impairment of the Tolerance of an Organism to Its Own Microflora Is a Kind of Immune Pathology, Fiziol. Chel., 2003, vol. 29, no.2, p. 138.Google Scholar
  34. 34.
    Sergeev, A.Yu. and Sergeev, Yu.V., Gribkovye infektsii (Fungal Infections), Moscow: Binom, 2003.Google Scholar
  35. 35.
    Jurk, M.F., Heil, J., Jollmer, C., et al., Human TLR7 or TLR8 Independently Confer Responsiveness to the Antiviral Compound R848, Nat. Immunol., 2002, vol. 3, p. 499.CrossRefPubMedGoogle Scholar
  36. 36.
    Krieg, A.M., CpC Motifs in DNA and Their Immune Effects, Annu. Rev. Immunol., vol. 20, p. 709.Google Scholar
  37. 37.
    Norn, S., Endotoxins Release Histamine by Complement Activation and Potential Bacteria-Induced Histamine Release, Agents Actions, 1986, vol. 18, no.1, p. 149.CrossRefPubMedGoogle Scholar

Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • I. D. Ponyakina
    • 1
  • L. G. Sagan
    • 1
  • K. A. Lebedev
    • 1
  1. 1.Clinical Diagnostic CenterMoscow State Medical Dental UniversityMoscowRussia

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