Skip to main content
Log in

Clinical Physiology: Role in Studying Basic Problems of the Regulation of Renal Functions in Humans

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Clinical physiology is described as a unique branch of human physiology that allows basic regulatory mechanisms of renal functions to be revealed. The analysis of physiological mechanisms that change the renal functions under the influence of endogenous or exogenous factors made it possible to detect new aspects of the regulatory system involved. The following problems are discussed: (1) the role of autacoids in the regulation of ion and water transport in the kidney; (2) the significance of functional loading tests for assessing the main components of the regulatory system of water and electrolyte balance; (3) the variety of sources of human blood hormones; and (4) the intranephron redistribution of water and electrolyte flows, which does not change their excretion by the kidney but affects the regulation of the totality of body functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Zaichik, A.Sh. and Churilov, A.P., Osnovy obshchei patologii (Basics of General Pathology), part 1: Osnovy obschei patofiziologii (Basics of General Pathophysiology), St. Petersburg: ELBI, 1999.

    Google Scholar 

  2. Chereshnev, V.A. and Yushkov, B.G. Patofiziologiya (Pathophysiology), Moscow: Veche, 2001.

    Google Scholar 

  3. Patologicheskaya fiziologiya. Uchebnik (Pathophysiology: A Manual), Ado, A.D., Ado, M.A., Pytskii, V.I., et al., Eds., Moscow: Triada-X, 2000.

    Google Scholar 

  4. Slovar' fiziologicheskikh terminov (Dictionary of Physiological Terms), Gazenko, O.G., Ed., Moscow: Nauka, 1987.

    Google Scholar 

  5. Osnovy fiziologii cheloveka. Uchebnik (Basics of Human Physiology: A Manual), vol. 3: Kliniko-fiziologicheskie aspekty (Clinical Physiological Aspects), Tkachenko, B.I., Ed., Moscow: Litera, 1998.

    Google Scholar 

  6. Vander, A., Fiziologiya pochek (Renal Physiology), St. Petersburg, 2000.

  7. DiBona, G.F. and Kopp, U.C., Neural Control of Renal Function, Physiol. Rev., 1997, vol. 238, p. F26.

    Google Scholar 

  8. Natochin, Yu.V., Renal Physiology, Fiziologiya vodnosolevogo obmena i pochki (Physiology of Water and Electrolyte Balance and Kidneys), Natochin, Yu.V., Ed., St. Petersburg: Nauka, 1993, p. 202.

    Google Scholar 

  9. Comprehensive Human Physiology, Greger, R. and Widhorst, U., Eds., Berlin, Heidelberg: Springer, 1996.

    Google Scholar 

  10. Dedov, I.I., Melnichenko, G.A., and Fadeev, V.V., Endokrinologiya (Endocrinology), Moscow: Meditsina, 2000.

    Google Scholar 

  11. Papayan, A.V. and Savenkova, N.D., Klinicheskaya nefrologiya detskogo vozrasta (Clinical Nephrology of Children), Moscow: Meditsina, 2000.

    Google Scholar 

  12. Djurhuus, J.C. and Rittig, S., Nocturnal Enuresis, Curr. Opin. Urol., 2002, vol. 12, no.4, p. 317.

    Article  PubMed  Google Scholar 

  13. Natochin, Yu.V. and Kuznetsova, A.A., Nocturnal Enuresis: Correction of Renal Function by Desmopressin and Diclofenac, Pediatr. Nephrol., 2000, vol. 14, no.1, p. 42.

    Article  PubMed  Google Scholar 

  14. Kuznetsova, A.A., Shakhmatova, E.I., Prutskova, N.P., and Natochin, Yu.V., Possible Role of Prostaglandins in Pathogenesis of Nocturnal Enuresis in Children, Scand. J. Urol. Nephrol., 2000, vol. 34, no.1, p. 27.

    Article  PubMed  Google Scholar 

  15. Natochin, Yu.V., New Data on Regulations in the Human Body, Vestn. Ros. Akad. Nauk, 2000, vol. 70, no.1, p. 21.

    Google Scholar 

  16. Jackson, E.K., Vasopressin and Other Agents Affecting the Renal Conservation of Water, The Pharmacological Basis of Therapeutics, Hardman, J.G., Goodman Gilman, A., and Limbird, L.E., Eds., 9th ed., New York: McGraw Hill, 1995, p. 715.

    Google Scholar 

  17. Kovacs, L. and Lichardus, B., Vasopressin: Disturbed Secretion and Its Effects, Dordrecht: Kluwer Academic, 1989.

    Google Scholar 

  18. Frolov, B.A., Fiziologiya i patologiya obmena natriya i vody v organizme (Physiology and Pathology of Sodium and Water Metabolism in the Body), Moscow: Meditsina, 2004.

    Google Scholar 

  19. Robertson, G.L., Athar, S., and Shelton, R.L., Osmotic Control of Vasopressin Function, Disturbances in Body Fluid Osmolality, Andreoli, T.A., Grantham, J.J., and Rector, F.C., Jr., Eds., Bethesda, Maryland: Am. Physiol. Soc., 1977, p. 125.

    Google Scholar 

  20. Kuznetsova, A.A. and Natochin, Yu.V., Physiological Analysis of Hyposmia in Pneumonia, Ter. Arkh., 2002, vol. 74, no.12, p. 56.

    Google Scholar 

  21. Timofeeva, N.M., Iezuitova, N.N., and Gromova, L.V., Current Concepts about Absorption of Monosaccharides, Amino Acids, and Peptides in the Mammalian Small Intestine, Usp. Fiziol. Nauk, 2000, vol. 31, no.4, p. 24.

    PubMed  Google Scholar 

  22. Natochin, Yu.V., Prutskova, N.P., Shakhmatova, E.I., et al., The Study on the In Vivo Absorption of Intact Nanopeptides in the Isolated Rat Small Intestine, Dokl. Ros. Akad. Nauk, 2003, vol. 388, no.4, p. 558.

    Google Scholar 

  23. Natochin, Yu.V., Grigoriev, A.I., Buravkova, L.B., et al., Antidiuretic Response of Human and Rat Kidneys to Oral Administration of Arg-Vasopressin and Desmopressin, Ros. Fiziol. Zh. im. I.M. Sechenova, 2003, vol. 89, no.2, p. 184.

    Google Scholar 

  24. Grigoriev, A.I., Larina, I.M., Buravkova, L.B., et al., Antidiuretic Response of Human Kidneys to Varied Modes of Vasopressin Administration, Ros. Fiziol. Zh. im. I.M. Sechenova, 2003, vol. 89, no.3, p. 89.

    Google Scholar 

  25. Roberts, P.R., Burney, J.D., Black, K.W., and Zaloga, G.P., Effect of Chain Length on Absorption of Biologically Active Peptides from the Gastrointestinal Tract, Digestion, 1999, vol. 60, no.4, p. 332.

    Article  PubMed  Google Scholar 

  26. Lee, V.H., Membrane Transporters, Eur. J. Pharm. Sci, 2000, vol. 11,suppl., p. S41.

    Article  PubMed  Google Scholar 

  27. Thamotharan, M., Bawani, S.Z., Zhou, X., and Adibi, S.A., Mechanism of Dipeptide Stimulation of Its Own Transport in a Human Intestinal Cell Line, Proc. Assoc. Am. Physicians, 1998, vol. 110, no.4, p. 361.

    PubMed  Google Scholar 

  28. Shyuk, O., Funktsional'noe issledovanie pochek (Functional Study of Kidneys), Prague, Avitsenum, 1975.

    Google Scholar 

  29. Natochin, Yu.V., Sokolova, M.M., Vasil'eva, V.F., and Balakhovskii, I.S., Examination of Renal Function in the Crew of the Space Ship Voskhod, Kosmich. Issled., 1965, vol. 3, no.6, p. 935.

    Google Scholar 

  30. Leach Huntoon, C.S., Grigoriev, A.I., and Natochin, Yu.V., Water and Electrolyte Balance Regulation in Space Flight, San Diego: Am. Astron. Soc., 1998.

    Google Scholar 

  31. Grigoriev, A.I., On Fundamental Studies in Space Physiology, Usp. Fiziol. Nauk., 1994, vol. 25, no.1, p. 112.

    Google Scholar 

  32. Morukov, B.V., Noskov, V.B., Larina, I.M., and Natochin, Yu.V., Water and Electrolyte Balance and Renal Function in Space Flights and Model Terrestrial Experiments, Ros. Fiziol. Zh. im. I.M. Sechenova, 2003, vol. 89, no.3, p. 356.

    Google Scholar 

  33. Natochin, Yu.V., Ionoreguliruyushchaya funktsiya pochki (Ionoregulatory Function of the Kidney), Leningrad: Nauka, 1976.

    Google Scholar 

  34. Grigoriev, A.I., Arzamazov, G.S., Dorokhova, B.R., et al., Metodicheskie rekomendatsii po ispol'zovaniyu vodnoi i vodno-solevoi nagruzochnykh prob pri otsenke funktsional'nogo sostoyaniya pochek u cheloveka (Methodical Recommendations Concerning Water and Water-Electrolyte Loading Tests in the Assessment of Renal Functions in Humans), Moscow: Inst. Biomed. Probl., 1979.

    Google Scholar 

  35. Gazenko, O.G., Grigoriev, A.I., and Natochin, Yu.V., Vodno-solevoi gomeostaz i kosmicheskii polet (Water and Electrolyte Homeostasis and Space Flight), Moscow: Nauka, 1986.

    Google Scholar 

  36. McKinley, M.J., Thirst: Physiological Aspects, London: Springer-Verlag, 1991.

    Google Scholar 

  37. Yamamoto, T. and Sasaki, S., Aquaporins in the Kidney: Emerging New Aspects, Kidney Int., 1998, vol. 54, p. 1041.

    Article  PubMed  Google Scholar 

  38. Almazov, V.A. and Shlyakhto, E.V., Arterial'naya gipertenziya i pochki (Arterial Hypertension and the Kidneys), St Petersburg: St. Petersburg. Gos. Med. Univ., 1999.

    Google Scholar 

  39. Blantz, R.C. and Gabbai, F.B., Renin-Angiotensin-Aldosterone System, Acid-Base and Electrolyte Disorders, DuBose, T.D. and Lee Hamm, L., Eds., Philadelphia: Saunders, 2002, p. 271.

    Google Scholar 

  40. Rose, B.D., Diuretics, Kidney Int., 1991, vol. 39, p. 336.

    PubMed  Google Scholar 

  41. Brenner Rector's The Kidney, Brenner, B.M., Ed., Philadelphia: Saunders, 2004, vol. 1.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

__________

Translated from Fiziologiya Cheloveka, Vol. 31, No. 5, 2005, pp. 80–87.

Original Russian Text Copyright © 2005 by Natochin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Natochin, Y.V. Clinical Physiology: Role in Studying Basic Problems of the Regulation of Renal Functions in Humans. Hum Physiol 31, 566–572 (2005). https://doi.org/10.1007/s10747-005-0098-9

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10747-005-0098-9

Keywords

Navigation