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Slow Cortical Potentials Preceeding Visually Guided Saccades in Schizophrenics

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Abstract

The parameters of saccades and presaccadic slow potentials were studied in right-handed men with a dominant right eye, including 19 schizophrenics and 12 healthy subjects. For visual stimulation, three light-emitting diodes were used, which were located in the center of the visual field (the central fixation stimulus) and 10° to the right and left of it (peripheral stimuli). Two stimulation protocols were used: with a simultaneous switching off of the central fixation stimulus and switching on of the peripheral stimuli (test 1) and with an interstimulus gap of 200 ms (test 2). According to the latency, saccades were divided into anticipatory, express, and regular. Slow EEG potentials preceding regular saccades were analyzed. It was found that the proportion of anticipatory saccades is considerably higher than the normal value in schizophrenia. The analysis of the presaccadic potentials demonstrated a significant decrease in the amplitude of negative potentials in the vertex region at early stages of presaccadic preparation and its increase in the occipital region at late stages. Test 2 in the patients demonstrated an increase in the positivity focus in the frontal region of the right hemisphere. It was assumed that the alterations found in schizophrenia result from the deficit of frontal cortical fields.

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REFERENCES

  1. Ivanova, M.P., Korkovye mekhanizmy proizvol'nykh dvizhenii u cheloveka (Cortical Mechanisms of Voluntary Movements in Humans), Moscow: Nauka, 1991.

    Google Scholar 

  2. Kirenskaya, A.V., Myamlin, V.V., Novototskii-Vlasov, V.Yu., et al., The Study of the Characteristics of Saccadic Eye Movement and the Preceding Negative Potentials in Schizophrenia, Ross. Psikhiatr. Zh., 2003, no. 6, p. 23.

  3. Slavutskaya, M.V. and Shul'govskii, V.V., Slow Negative Potentials of the Human Brain during the Fixation and the Preparation of Saccades in Response to Visual Stimuli, Zh. Vyssh. Nervn. Deyat., 2002, vol. 52, issue5, p. 551.

    Google Scholar 

  4. Slavutskaya, M.V. and Shul'govskii, V.V., Positive Potentials of the Human Brain at Different Stages of the Preparation of a Visually Induced Saccade, Zh. Vyssh. Nervn. Deyat., 2003, vol. 53, issue3, p. 341.

    Google Scholar 

  5. Evdokimidis, I., Mergner, T., and Lucking, E.N., Dependence of Presaccadic Cortical Potentials on the Type of Saccadic Eye Movement, EEG Clin. Neurophysiol., 1992, vol. 83, p. 179.

    Article  Google Scholar 

  6. Shibasaki, H., Barrett, G., Halliday, E., and Halliday, A., Components of the Movement-Related Cortical Potentials and Their Scalp Topography, EEG Clin. Neurophysiol., 1980, vol. 49, no.3, p. 213.

    Article  Google Scholar 

  7. Broerse, A., Crawford, T.J., and den Boer, J.A., Parsing Cognition in Schizophrenia Using Saccadic Eye Movements: A Selective Overview, Neuropsychologia, 2001, vol. 39, p. 742.

    Article  PubMed  Google Scholar 

  8. Everling, S. and Fischer, B., The Antisaccade: A Review of Basic Research and Clinical Studies, Neuropsychologia, 1998, vol. 36, no.9, p. 885.

    Article  PubMed  Google Scholar 

  9. Holzman, P.S., On the Trail of the Genetics and Pathophysiology of Schizophrenia, Psychiatry, 1996, vol. 59, no.2, p. 117.

    PubMed  Google Scholar 

  10. Klein, C., Heinks, T., Andersen, B., and Berg, P., Impaired Modulation of Saccadic Contingent Negative Variation Preceding Antisaccade in Schizophrenia, Biol. Psychiatry, 2000, vol. 47, no.11, p. 978.

    Article  PubMed  Google Scholar 

  11. Clementz, B.A., McDowell, J.E., and Zisook, S., Saccadic System Functioning among Schizophrenia Patients and Their First-Degree Biological Relatives, J. Abnormal Psychol., 1994, vol. 103, p. 277.

    Article  Google Scholar 

  12. Andreasen, N.C., O'Leary, D., Cizadlo, T., et al., Schizophrenia and Cognitive Dysmetria: A Positron-Emission Tomography Study of Dysfunctional Prefrontal-Thalamic-Cerebellar Circuitry, Proc. Natl. Acad. Sci. USA, 1996, vol. 93, no.9, p. 985.

    Article  PubMed  Google Scholar 

  13. Kasai, K., Iwanami, A., Yamasue, H., et al., Neuroanatomy and Neurophysiology in Schizophrenia, Neurosci. Res., 2002, vol. 43, p. 93.

    Article  PubMed  Google Scholar 

  14. Kovelman, J.A. and Scheibel, A.B., Biological Substrates of Schizophrenia, Acta Neurol. Scand., 1986, vol. 71, no.1, p. 1.

    Google Scholar 

  15. Ruchkin, D.S., Sutton, S., Mahaffey, D., and Glaser, J., Terminal CNV in the Absence of Motor Response, EEG Clin. Neurophysiol., 1986, vol. 63, p. 445.

    Article  Google Scholar 

  16. Malaspina, D., Storer, D., Furman, V., et al., SPECT Study of Visual Fixation in Schizophrenia and Comparison Subjects, Biol. Psychiatry, 1999, vol. 46, p. 89.

    Article  PubMed  Google Scholar 

  17. Barrett, G., Shibasaki, H., and Neshige, R., Cortical Potentials Preceding Voluntary Movement: Evidence for Three Periods of Preparation in Man, EEG Clin. Neurophysiol., 1986, vol. 63, no.4, p. 327.

    Article  Google Scholar 

  18. Goldberg, M.E. and Segraves, M.A., The Visual and Frontal Cortex, in Neurobiology of Saccadic Eye Movements: Reviews of Oculomotor Research, 1989, vol. 2, p. 283.

    Google Scholar 

  19. McDowell, J. and Clementz, B., Behavioral and Brain Imaging Studies of Saccadic Performance in Schizophrenia, Biol. Psychol., 2001, vol. 57, p. 5.

    Article  PubMed  Google Scholar 

  20. Colby, C.L., Duchamel, J.R., and Goldberg, M.E., Multiple Parietal Representation of Space, Brain Theory: Biological Basis and Computational Principles, Aerlen, A. and Bradenberg, M., Eds., Amsterdam: Elsevier, 1996, p. 37.

    Google Scholar 

  21. Rushworth, M., Nixon, P.D., Renowden, S., et al., The Left Parietal Cortex and Motor Attention, Neuropsychologia, 1997, vol. 35, no.9, p. 1261.

    Article  PubMed  Google Scholar 

  22. Tucker, D.M., Hemisphere Specialization: A Mechanism for Unifying Anterior and Posterior Brain Regions, Duality and Unity of the Brain, Otton, D., Ed., London: McMillan, 1987, p. 180.

    Google Scholar 

  23. Fischer, B. and Breitmeyer, B., Mechanism of Visual Attention Revealed by Saccadic Eye Movement, Neuropsychology, 1987, vol. 25, p. 73.

    Article  Google Scholar 

  24. Rohrer, W.H. and Sparks, D.L., Express Saccades: The Effects of Spatial and Temporal Uncertainty, Vision Res., 1993, vol. 33, no.17, p. 2447.

    Article  PubMed  Google Scholar 

  25. Spantekow, A., Krappmann, P., Everling, S., and Flohr, H., Event-Related Potentials and Saccadic Reaction Times: Effects of Fixation Point Offset or Change, Exp. Brain Res., 1999, vol. 127, no.3, p. 291.

    Article  PubMed  Google Scholar 

  26. Munoz, D.P., Dorris, M.C., Pare, M., and Everling, S., On Your Mark, Get Set: Brainstem Circuitry Underlying Saccadic Initiation, Can. J. Physiol. Pharmacol., 2000, vol. 78, p. 934.

    Article  PubMed  Google Scholar 

  27. Gray, J., Hemsley, D., Feldon, J., et al., Neuropsychology of Schizophrenia, Behav. Brain Sci., 1991, vol. 14, no.1, p. 2.

    Google Scholar 

  28. Konishi, S., Nakajima, K., Uchida, I., et al., No-Go Dominant Brain Activity in Human Inferior Prefrontal Cortex Revealed by Functional Magnetic Resonance Imaging, Eur. J. Neurosci., 1998, vol. 10, p. 1209.

    Article  PubMed  Google Scholar 

  29. Meador, K.J., Loring, D.W., Lee, G.P., et al., Hemisphere Asymmetry for Eye Gaze Mechanisms, Brain, 1989, vol. 112, no.1, p. 103.

    PubMed  Google Scholar 

  30. Posner, M., Orienting of Attention, J. Exp. Psychol., 1980, vol. 32, p. 3.

    Google Scholar 

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Authors and Affiliations

  1. Moscow State University, Moscow, 119899, Russia

    M. V. Slavutskaya & V. V. Shul'govskii

  2. Serbskii State Research Center of Social and Forensic Psychiatry, Moscow, Russia

    A. V. Kirenskaya & V. Yu. Novototskii-Vlasov

  3. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    I. B. Kozlovskaya

Authors
  1. M. V. Slavutskaya
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  2. A. V. Kirenskaya
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  3. V. Yu. Novototskii-Vlasov
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  4. V. V. Shul'govskii
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  5. I. B. Kozlovskaya
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__________

Translated from Fiziologiya Cheloveka, Vol. 31, No. 5, 2005, pp. 58–67.

Original Russian Text Copyright © 2005 by Slavutskaya, Kirenskaya, Novototskii-Vlasov, Shul'govskii, Kozlovskaya.

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Slavutskaya, M.V., Kirenskaya, A.V., Novototskii-Vlasov, V.Y. et al. Slow Cortical Potentials Preceeding Visually Guided Saccades in Schizophrenics. Hum Physiol 31, 545–553 (2005). https://doi.org/10.1007/s10747-005-0095-z

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  • DOI: https://doi.org/10.1007/s10747-005-0095-z

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