Abstract
Computer-assisted superimposition of the equivalent dipole sources (EDSs) of the main pathological EEG patterns with the results of computer tomography and magnetic resonance imaging of the brain was performed for patients with organic CNS lesions. The greatest degree of structural determination was revealed for local and lateralized (in a traumatic injury) slow waves, whose EDSs mapped to the perifocal zone of the injury focus. The EDSs of epileptiform patterns could be located in the zone of damaged brain substance or in the intact hemisphere (when the limbic structures were damaged), reflecting the formation of secondary functional foci in the latter case. Bilateral paroxysmal patterns were more frequently determined by the functional state of the medial brain structures. The EDSs of pathological (diencephalic, hippocampal) α activity were closely associated with the corresponding anatomical brain structures, although without a strict dependence on the degree of their morphological intactness.
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REFERENCES
Gutman, A.M., Biofizika vnekletochnykh tokov mozga (Biophysics of Extracellular Currents of the Brain), Moscow: Nauka, 1980.
Gnezditskii, V.V., Koptelov, Yu.M., and Novozhilov, V.I., Possibilities of Three-Dimensional Localization of the EEG Sources Based on the Equivalent Dipole Model, Zh. Vyssh. Nervn. Deyat., 1981, vol. 31, no. 2, p. 323.
Nunez, P.L., A Study of Origins of the Time Dependencies of Scalp EEG: Theoretical Basis, IEEE Trans. Biomed. Eng., 1981, vol. BME-28, p. 271.
Koptelov, Yu.M. and Gnezditskii, V.V., Analysis of Scalp Potential Fields and Three-Dimensional Localization of the Sources of Epileptic Activity of the Human Brain, Zh. Nevropatol. Psikhiatr., 1989, vol. 89, no. 6, p. 11.
Pirlik, G.P., Gnezditskii, V.V., Koptelov, Yu.M., et al., Heterogeneity of Local EEG Changes in Patients with a Stroke of Hemispherical Localization as Evidenced by Mapping and Dipole Localization (BrainLoc), Zh. Nevropatol. Psikhiatr., 2001, vol. 101, no. 2, p. 98.
Gambarelly, Y., Gurinel, G., Cherrot, L., and Mattei, M., Computerized Axial Tomography (An Anatomic Atlas of Sections of the Human Body: Anatomy-Rachiology-Scans), Berlin, 1977.
Boldyreva, G., “The Hippocampal α Rhythm” of the Human Brain, EEG Clin. Neurophysiol., 1997, vol. 103, no. 1, p. 199.
Maiorchik, V.E., Physiological Assessment of the EEG Changes in Human Brain Tumors, in Klinicheskaya elektroentsefalografiya (Clinical Electroencephalography), Moscow: Meditsina, 1973, p. 82.
Gilmore, P.C. and Brenner, R.P., Correlation of EEG, Computerized Tomography, and Clinical Finding: Study of 100 Patients with Focal δ Activity, Arch. Neurol., 1981, vol. 38, no. 6, p. 371. (Available from www.pubmed.com).
Sumskii, L.I., Koptelov, Yu.M., and Baev, A.A., Correlation between the Data of Topographic Mapping, Three-Dimensional Localization, and Magnetic Resonance Imaging in Epileptic Patients, Trudy konferentsii “Sovremennoesostoyanie metodov neinvazivnoi diagnostiki v meditsine” (Proc. Conf. “Current State of Methods for Noninvasive Diagnosis in Medicine”), Gurzuf, 1997, p. 25.
Gnezditskii, V.V., Obratnaya zadacha EEG i klinicheskaya elektroentsefalografiya (EEG Inverse Problem and Clinical Electroencephalography), Taganrog: TGRU, 2000.
Saradzhishvili, P.M., About the Functional Significance of Secondary Epileptic Foci, Zh. Nevropatol. Psikhiatr., 1971, vol. 71, no. 8, p. 1127.
Zenkov, L.R., Klinicheskaya elektroentsefalografiya s elementami epileptologii (Clinical Electroencephalography with Epileptology Elements), Taganrog: TGRU, 1996.
Boldyreva, G.N., Elektricheskaya aktivnost’ mozga chelovekapri porazhenii dientsefal’nykh i limbicheskikh struktur (Electrical Activity of the Human Brain in Diencephalic and Limbic Structure Lesions), Moscow: Nauka, 2000.
Boldyreva, G.N., The Role of Diencephalic Structures in the Organization of the Human Brain Electrical Activity, in Elertrofiziologicheskoe issledovanie statsionarnoi aktivnost v golovnom mozge (Electrophysiological Study of Stationary Activity in the Brain), Moscow: Nauka, 1983, p. 222.
Grindel’, O.M, Bragina, N.N., Voronina, I.A., et al., Electroencephalographic Correlates of Disorders of Higher Cortical Functions in Local Lesions of the Hypothalamic Region, Zh. Vyssh. Nervn. Deyat., 1995, vol. 45, issue 6, p. 1101.
Puchinskaya, L.M., Grindel’, O.M., Vakar, E.M., and Volkova, L.D., Characteristic of the Transition State from Wakefulness to Drowsiness according to the EEG Data, Fiziol. Chel., 1976, vol. 2, no. 3, p. 347.
Boldyreva, G.N., Bragina, N.N., Margishvili, G.M., and Masherov, E.L., The Influence of the Stationary Excitation Focus in Limbic Structures on Changes in the Spatial-Temporal Organization of Human EEG, Fiziol.Chel., 1995, vol. 21, no. 5, p. 18.
Frolov, A.A., Boldyreva, G.N., and Koptelov, Yu.M., A Search for Sources of Pathological α Activity in the Human EEG in Limbic Lesions, Zh. Vyssh. Nervn. Deyat., 1998, vol. 48, issue 4, p. 687.
Boldyreva, G.N., Frolov, A.A., and Koptelov, Yu.M., The Pathologic α Activity in EEG of Patients with Limbic Lesions, Abstracts Int. J. Psychophysiol., 1998, vol. 30, p. 164.
Roth, B.J., Dipole Localization in Patients with Epilepsy Using the Realistically Shaped Head Model, EEG and Clin. Neurophysiol., 1997, vol. 102, p. 159.
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Translated from Fiziologiya Cheloveka, Vol. 31, No. 1, 2005, pp. 24–32.
Original Russian Text Copyright © 2005 by Boldyreva, Sharova, Koptelov, Shchepetkov, Nikitin, Kornienko, Fadeeva.
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Boldyreva, G.N., Sharova, E.V., Koptelov, Y.M. et al. Study of the genesis of pathological EEG patterns in tumor and traumatic lesions of the human brain. Hum Physiol 31, 18–25 (2005). https://doi.org/10.1007/s10747-005-0003-6
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DOI: https://doi.org/10.1007/s10747-005-0003-6