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Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure

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Abstract

Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions.

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Funding

The current study was supported by the Natural Science Foundation of Shandong Province (ZR2023QH190).

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  1. Yan-Bing Liu, Qian Wang and Yu-Ling Song equally contributed to the present work.

Authors and Affiliations

  1. Interventional Medical Center, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China

    Yan-Bing Liu & Zhen-Kang Qiu

  2. Medical College, Qingdao University, Qingdao, China

    Yan-Bing Liu, Qian Wang, Xiao-Min Song, Yu-Chen Fan, Lin Kong, Jing-Sai Zhang, Sheng Li, Yi-Ju Lv & Ze-Yang Li

  3. Department of Pediatrics, Huantai County Hospital of Traditional Chinese Medicine, Zibo, China

    Yu-Ling Song

  4. Department of Oncology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China

    Jing-Yu Dai

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Contributions

Yan-Bing Liu conceptualized the topic and idea and prepared the first draft and all figures. Qian Wang and Yu-Ling Song were responsible for reference research and information collection. Xiao-Min Song, Yu-Chen Fan, Lin Kong, Jing-Sai Zhang, Sheng Li, Yi-Ju Lv, and Ze-Yang Li were responsible for editing the first draft and finalizing the manuscript. Jing-Yu Dai revised and polished the language of the manuscript. Jing-Yu Dai and Zhen-Kang Qiu approved the final version.

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Correspondence to Jing-Yu Dai or Zhen-Kang Qiu.

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Yan-Bing Liu, Qian Wang, Yu-Ling Song, Xiao-Min Song, Yu-Chen Fan, Lin Kong, Jing-Sai Zhang, Sheng Li, Yi-Ju Lv, Ze-Yang Li, Jing-Yu Dai, and Zhen-Kang Qiu have no conflicts of interest or financial ties to disclose.

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Liu, YB., Wang, Q., Song, YL. et al. Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure. Heart Fail Rev (2024). https://doi.org/10.1007/s10741-024-10395-w

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