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Effects of SGLT2 inhibitors on cardiac structure and function

Abstract

SGLT2 inhibitors reduce cardiovascular death or hospitalization for heart failure, regardless of the presence or absence of diabetes in patients at high cardiovascular risk and in those with heart failure and reduced ejection fraction (HFrEF). In patients with HF and preserved EF, empagliflozin also showed favorable effects mainly related to the reduction of hospitalization for heart failure. These favorable effects are beyond the reduction of glycemic levels and mainly related to beneficial hemodynamic and anti-inflammatory effects of these drugs and improved cardiac energy metabolism. In this review, we aimed to evaluate the effects of SGLT2 inhibitor on cardiac remodeling and function, which is still incompletely clear.

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References

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Contributions

Novo: conception of the study, design, and supervision. Guarino: literature review and writer especially concerning diastolic function. Di Lisi: literature review and writer especially concerning strain analysis and tables. Biagioli: literature review and writer especially concerning systolic function. Carluccio: supervision and critical review.

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Correspondence to Tommaso Guarino.

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Novo, G., Guarino, T., Di Lisi, D. et al. Effects of SGLT2 inhibitors on cardiac structure and function. Heart Fail Rev (2022). https://doi.org/10.1007/s10741-022-10256-4

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Keywords

  • SGLT2 inhibitors
  • Heart failure
  • Left ventricle
  • Cardiac remodeling
  • Ejection fraction
  • Systolic function
  • Diastolic function