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Right ventricular diastolic dysfunction and failure: a review

Abstract

Right ventricular diastolic dysfunction and failure (RVDDF) has been increasingly identified in patients with cardiovascular diseases, including heart failure and other diseases with cardiac involvement. It is unknown whether RVDDF exists as a distinct clinical entity; however, its presence and degree have been shown to be a sensitive marker of end-organ dysfunction related to multiple disease processes including systemic hypertension, pulmonary hypertension, heart failure, and endocrine disease. In this manuscript, we review issues pertaining to RVDDF including anatomic features of the right ventricle, physiologic measurements, RVDDF diagnosis, underlying mechanisms, clinical impact, and clinical management. Several unique features of RVDDF are also discussed.

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YJ, XR, and WDG were involved in initial conception and design, literature search and review, and finalization of scope of the manuscript; YJ and XR contributed equally; YJ, XR, GC, JMD, and WDG were involved in writing the manuscript; GC, JMD, and WDG edited and finalized the manuscript.

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Correspondence to Wei Dong Gao.

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Jung, YH., Ren, X., Suffredini, G. et al. Right ventricular diastolic dysfunction and failure: a review. Heart Fail Rev 27, 1077–1090 (2022). https://doi.org/10.1007/s10741-021-10123-8

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Keywords

  • Heart failure
  • Right ventricular diastolic dysfunction
  • Right ventricular diastolic failure
  • Right heart failure