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Long non-coding RNAs in cardiac hypertrophy

Heart Failure Reviews volume 25, pages 1037–1045 (2020)Cite this article

Abstract

Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecular mechanisms involved in CH are unclear. Recently, increasing evidences reveal that long non-coding RNAs (lncRNAs) play vital roles in CH. Different lncRNAs can promote or inhibit the pathological process of CH by different mechanisms, while the regulation of lncRNAs expression can improve CH. Thus, CH-related lncRNAs may become a novel field of research on CH.

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Funding

This work was supported by the National Natural Sciences Foundation of China (grant number 81874410).

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  1. Cardiovascular Disease Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian District, Beijing, 100091, China

    Jinghui Sun & Chenglong Wang

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  1. Jinghui Sun
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Sun, J., Wang, C. Long non-coding RNAs in cardiac hypertrophy. Heart Fail Rev 25, 1037–1045 (2020). https://doi.org/10.1007/s10741-019-09882-2

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Keywords

  • Cardiac hypertrophy
  • Long non-coding RNAs
  • Heart failure
  • Cardiac remodeling