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Exercise intervention in hospitalized heart failure patients, with emphasis on congestion-related complications: a review

  • Jirka CopsEmail author
  • Sibren Haesen
  • Bart De Moor
  • Wilfried Mullens
  • Dominique Hansen
Article
  • 185 Downloads

Abstract

The importance of physical activity has become evident since a sedentary lifestyle drives cardiovascular disease progression and is associated with increased morbidity and mortality. The favorable effects of exercise training in chronic heart failure (HF) and chronic kidney disease (CKD) are widely recognized and exercise training is recommended by European and American guidelines. However, the application of exercise intervention in HF patients hospitalized for acute decompensation or acute worsening in cardiac function has not been explored extensively and, as a result, knowledge about the effects of exercise training in the inpatient setting of acute HF is limited. Acute HF is often accompanied by signs and symptoms of congestion, termed acute decompensated heart failure (ADHF), which leads to worsening renal function (WRF) and eventually negatively affects both thoracic and abdominal organs. Therefore, we first provide a comprehensive overview of the impact of exercise training in hospitalized patients demonstrating acute decompensating HF. In the second part, we will focus on the effects of exercise training on congestion in a setting of ADHF complicated by renal dysfunction. This review suggests that exercise intervention is beneficial in the inpatient setting of acute HF, but that more clinical studies focusing on the application of exercise training to counteract venous congestion are needed.

Keywords

Exercise training Electrical muscle stimulation Acute decompensating heart failure Venous congestion Worsening renal function 

Notes

Funding

This work was funded by Bijzonder Onderzoeks Fonds (BOF) from UHasselt/BIOMED to JC.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Since this is a review article, this article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Haykowsky MJ, Liang Y, Pechter D, Jones LW, McAlister FA, Clark AM (2007) A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed. J Am Coll Cardiol 49(24):2329–2336.  https://doi.org/10.1016/j.jacc.2007.02.055 CrossRefPubMedGoogle Scholar
  2. 2.
    Belardinelli R, Georgiou D, Cianci G, Purcaro A (2012) 10-year exercise training in chronic heart failure: a randomized controlled trial. J Am Coll Cardiol 60(16):1521–1528.  https://doi.org/10.1016/j.jacc.2012.06.036 CrossRefPubMedGoogle Scholar
  3. 3.
    Howden EJ, Coombes JS, Isbel NM (2015) The role of exercise training in the management of chronic kidney disease. Curr Opin Nephrol Hypertens 24(6):480–487.  https://doi.org/10.1097/mnh.0000000000000165 CrossRefPubMedGoogle Scholar
  4. 4.
    Howden EJ, Fassett RG, Isbel NM, Coombes JS (2012) Exercise training in chronic kidney disease patients. Sports Med (Auckland, NZ) 42(6):473–488.  https://doi.org/10.2165/11630800-000000000-00000 CrossRefGoogle Scholar
  5. 5.
    Morishita Y, Nagata D (2015) Strategies to improve physical activity by exercise training in patients with chronic kidney disease. Int J Nephrol Renov Dis 8:19–24.  https://doi.org/10.2147/ijnrd.S65702 CrossRefGoogle Scholar
  6. 6.
    Lewinter C, Doherty P, Gale CP, Crouch S, Stirk L, Lewin RJ, LeWinter MM, Ades PA, Kober L, Bland JM (2015) Exercise-based cardiac rehabilitation in patients with heart failure: a meta-analysis of randomised controlled trials between 1999 and 2013. Eur J Prev Cardiol 22(12):1504–1512.  https://doi.org/10.1177/2047487314559853 CrossRefPubMedGoogle Scholar
  7. 7.
    Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, Davos CH, Dalal HM, Dracup K, Evangelista LS, Jolly K, Myers J, Nilsson BB, Passino C, Witham MD, Yeh GY (2019) Impact of exercise rehabilitation on exercise capacity and quality-of-life in heart failure: individual participant meta-analysis. J Am Coll Cardiol 73(12):1430–1443.  https://doi.org/10.1016/j.jacc.2018.12.072 CrossRefPubMedGoogle Scholar
  8. 8.
    O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301(14):1439–1450.  https://doi.org/10.1001/jama.2009.454 CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, O'Connor C, Whellan D, Keteyian SJ, Coats A, Davos CH, Dalal HM, Dracup K, Evangelista L, Jolly K, Myers J, McKelvie RS, Nilsson BB, Passino C, Witham MD, Yeh GY, Zwisler AO (2018) Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials. Eur J Heart Fail 20(12):1735–1743.  https://doi.org/10.1002/ejhf.1311 CrossRefPubMedGoogle Scholar
  10. 10.
    Edelmann F, Gelbrich G, Dungen HD, Frohling S, Wachter R, Stahrenberg R, Binder L, Topper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Loffler M, Hasenfuss G, Halle M, Pieske B (2011) Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol 58(17):1780–1791.  https://doi.org/10.1016/j.jacc.2011.06.054 CrossRefPubMedGoogle Scholar
  11. 11.
    Nolte K, Herrmann-Lingen C, Wachter R, Gelbrich G, Dungen HD, Duvinage A, Hoischen N, von Oehsen K, Schwarz S, Hasenfuss G, Halle M, Pieske B, Edelmann F (2015) Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial. Eur J Prev Cardiol 22(5):582–593.  https://doi.org/10.1177/2047487314526071 CrossRefPubMedGoogle Scholar
  12. 12.
    Pandey A, Parashar A, Kumbhani D, Agarwal S, Garg J, Kitzman D, Levine B, Drazner M, Berry J (2015) Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circ Heart Fail 8(1):33–40.  https://doi.org/10.1161/circheartfailure.114.001615 CrossRefPubMedGoogle Scholar
  13. 13.
    Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G, Kraus WE, Eggebeen J, Nicklas BJ (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. Jama 315(1):36–46.  https://doi.org/10.1001/jama.2015.17346 CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Tucker WJ, Nelson MD, Beaudry RI, Halle M, Sarma S, Kitzman DW, Gerche A, Haykowksy MJ (2016) Impact of exercise training on peak oxygen uptake and its determinants in heart failure with preserved ejection fraction. Cardiac Fail Rev 2(2):95–101.  https://doi.org/10.15420/cfr.2016:16:2 CrossRefGoogle Scholar
  15. 15.
    Piepoli MF, Corra U, Benzer W, Bjarnason-Wehrens B, Dendale P, Gaita D, McGee H, Mendes M, Niebauer J, Zwisler AD, Schmid JP (2010) Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil 17(1):1–17.  https://doi.org/10.1097/HJR.0b013e3283313592 CrossRefPubMedGoogle Scholar
  16. 16.
    De Maeyer C, Beckers P, Vrints CJ, Conraads VM (2013) Exercise training in chronic heart failure. Ther Adv Chronic Dis 4(3):105–117.  https://doi.org/10.1177/2040622313480382 CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Johansen KL (2007) Exercise in the end-stage renal disease population. J Am Soc Nephrol 18(6):1845–1854.  https://doi.org/10.1681/asn.2007010009 CrossRefPubMedGoogle Scholar
  18. 18.
    Ouzouni S, Kouidi E, Sioulis A, Grekas D, Deligiannis A (2009) Effects of intradialytic exercise training on health-related quality of life indices in haemodialysis patients. Clin Rehabil 23(1):53–63.  https://doi.org/10.1177/0269215508096760 CrossRefPubMedGoogle Scholar
  19. 19.
    Heiwe S, Jacobson SH (2011) Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev (10):Cd003236.  https://doi.org/10.1002/14651858.CD003236.pub2
  20. 20.
    Kosmadakis GC, Bevington A, Smith AC, Clapp EL, Viana JL, Bishop NC, Feehally J (2010) Physical exercise in patients with severe kidney disease. Nephron Clin Pract 115(1):c7–c16.  https://doi.org/10.1159/000286344 CrossRefPubMedGoogle Scholar
  21. 21.
    Heiwe S, Jacobson SH (2014) Exercise training in adults with CKD: a systematic review and meta-analysis. Am J Kidney Dis 64(3):383–393.  https://doi.org/10.1053/j.ajkd.2014.03.020 CrossRefPubMedGoogle Scholar
  22. 22.
    Kirkman DL, Edwards DG, Lennon-Edwards S (2014) Exercise as an adjunct therapy in chronic kidney disease. Ren Nutr Forum 33(4):1–8Google Scholar
  23. 23.
    Pechter U, Ots M, Mesikepp S, Zilmer K, Kullissaar T, Vihalemm T, Zilmer M, Maaroos J (2003) Beneficial effects of water-based exercise in patients with chronic kidney disease. Int J Rehabil Res 26(2):153–156.  https://doi.org/10.1097/01.mrr.0000070755.63544.5a CrossRefPubMedGoogle Scholar
  24. 24.
    Toyama K, Sugiyama S, Oka H, Sumida H, Ogawa H (2010) Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease. J Cardiol 56(2):142–146.  https://doi.org/10.1016/j.jjcc.2010.06.007 CrossRefPubMedGoogle Scholar
  25. 25.
    Matsuzawa R, Roshanravan B, Shimoda T, Mamorita N, Yoneki K, Harada M, Watanabe T, Yoshida A, Takeuchi Y, Matsunaga A (2018) Physical activity dose for hemodialysis patients: where to begin? Results from a prospective cohort study. J Ren Nutr 28(1):45–53.  https://doi.org/10.1053/j.jrn.2017.07.004 CrossRefPubMedGoogle Scholar
  26. 26.
    Konstantinidou E, Koukouvou G, Kouidi E, Deligiannis A, Tourkantonis A (2002) Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitation programs. J Rehabil Med 34(1):40–45CrossRefGoogle Scholar
  27. 27.
    Anding K, Bar T, Trojniak-Hennig J, Kuchinke S, Krause R, Rost JM, Halle M (2015) A structured exercise programme during haemodialysis for patients with chronic kidney disease: clinical benefit and long-term adherence. BMJ Open 5(8):e008709.  https://doi.org/10.1136/bmjopen-2015-008709 CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Bae YH, Lee SM, Jo JI (2015) Aerobic training during hemodialysis improves body composition, muscle function, physical performance, and quality of life in chronic kidney disease patients. J Phys Ther Sci 27(5):1445–1449.  https://doi.org/10.1589/jpts.27.1445 CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Manfredini F, Mallamaci F, D'Arrigo G, Baggetta R, Bolignano D, Torino C, Lamberti N, Bertoli S, Ciurlino D, Rocca-Rey L, Barilla A, Battaglia Y, Rapana RM, Zuccala A, Bonanno G, Fatuzzo P, Rapisarda F, Rastelli S, Fabrizi F, Messa P, De Paola L, Lombardi L, Cupisti A, Fuiano G, Lucisano G, Summaria C, Felisatti M, Pozzato E, Malagoni AM, Castellino P, Aucella F, Abd ElHafeez S, Provenzano PF, Tripepi G, Catizone L, Zoccali C (2017) Exercise in patients on dialysis: a multicenter, randomized clinical trial. J Am Soc Nephrol 28(4):1259–1268.  https://doi.org/10.1681/asn.2016030378 CrossRefPubMedGoogle Scholar
  30. 30.
    Parker K (2016) Intradialytic exercise is medicine for hemodialysis patients. Curr Sports Med Rep 15(4):269–275.  https://doi.org/10.1249/jsr.0000000000000280 CrossRefPubMedGoogle Scholar
  31. 31.
    Storer TW, Casaburi R, Sawelson S, Kopple JD (2005) Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients. Nephrol Dial Transplant 20(7):1429–1437.  https://doi.org/10.1093/ndt/gfh784 CrossRefPubMedGoogle Scholar
  32. 32.
    Kouidi E, Karagiannis V, Grekas D, Iakovides A, Kaprinis G, Tourkantonis A, Deligiannis A (2010) Depression, heart rate variability, and exercise training in dialysis patients. Eur J Cardiovasc Prev Rehabil 17(2):160–167.  https://doi.org/10.1097/HJR.0b013e32833188c4 CrossRefPubMedGoogle Scholar
  33. 33.
    Parsons TL, Toffelmire EB, King-VanVlack CE (2006) Exercise training during hemodialysis improves dialysis efficacy and physical performance. Arch Phys Med Rehabil 87(5):680–687.  https://doi.org/10.1016/j.apmr.2005.12.044 CrossRefPubMedGoogle Scholar
  34. 34.
    Thangarasa T, Imtiaz R, Hiremath S, Zimmerman D (2018) Physical activity in patients treated with peritoneal dialysis: a systematic review and meta-analysis. Can J Kidney Health Dis 5:2054358118779821.  https://doi.org/10.1177/2054358118779821 CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Shahgholian N, KarimiFard O, Shahidi S (2015) Effects of aerobic exercise on blood glucose in continuous ambulatory peritoneal dialysis patients. Iran J Nurs Midwifery Res 20(2):165–170PubMedPubMedCentralGoogle Scholar
  36. 36.
    Stevens PE, Levin A (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158(11):825–830.  https://doi.org/10.7326/0003-4819-158-11-201306040-00007 CrossRefGoogle Scholar
  37. 37.
    Van Craenenbroeck AH, Van Craenenbroeck EM, Kouidi E, Vrints CJ, Couttenye MM, Conraads VM (2014) Vascular effects of exercise training in CKD: current evidence and pathophysiological mechanisms. Clin J Am Soc Nephrol 9(7):1305–1318.  https://doi.org/10.2215/cjn.13031213 CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Roger VL (2013) Epidemiology of heart failure. Circ Res 113(6):646–659.  https://doi.org/10.1161/circresaha.113.300268 CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Farmakis D, Parissis J, Lekakis J, Filippatos G (2015) Acute heart failure: epidemiology, risk factors, and prevention. Rev Esp Cardiol (English ed) 68(3):245–248.  https://doi.org/10.1016/j.rec.2014.11.004 CrossRefGoogle Scholar
  40. 40.
    Kurmani S, Squire I (2017) Acute heart failure: definition, classification and epidemiology. Curr Heart Fail Rep 14(5):385–392.  https://doi.org/10.1007/s11897-017-0351-y CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Reeves GR, Whellan DJ, O'Connor CM, Duncan P, Eggebeen JD, Morgan TM, Hewston LA, Pastva A, Patel MJ, Kitzman DW (2017) A novel rehabilitation intervention for older patients with acute decompensated heart failure: the REHAB-HF pilot study. JACC Heart Fail 5(5):359–366.  https://doi.org/10.1016/j.jchf.2016.12.019 CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Kress JP, Hall JB (2014) ICU-acquired weakness and recovery from critical illness. N Engl J Med 370(17):1626–1635.  https://doi.org/10.1056/NEJMra1209390 CrossRefPubMedGoogle Scholar
  43. 43.
    Latronico N, Bolton CF (2011) Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 10(10):931–941.  https://doi.org/10.1016/s1474-4422(11)70178-8 CrossRefPubMedGoogle Scholar
  44. 44.
    Montuclard L, Garrouste-Orgeas M, Timsit JF, Misset B, De Jonghe B, Carlet J (2000) Outcome, functional autonomy, and quality of life of elderly patients with a long-term intensive care unit stay. Crit Care Med 28(10):3389–3395CrossRefGoogle Scholar
  45. 45.
    Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE, Bulger E, Kozar RA (2013) Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care (London, England) 17(5):R206.  https://doi.org/10.1186/cc12901 CrossRefGoogle Scholar
  46. 46.
    Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet (London, England) 373(9678):1874–1882.  https://doi.org/10.1016/s0140-6736(09)60658-9 CrossRefGoogle Scholar
  47. 47.
    Calvo-Ayala E, Khan BA, Farber MO, Ely EW, Boustani MA (2013) Interventions to improve the physical function of ICU survivors: a systematic review. Chest 144(5):1469–1480.  https://doi.org/10.1378/chest.13-0779 CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Burtin C, Clerckx B, Robbeets C, Ferdinande P, Langer D, Troosters T, Hermans G, Decramer M, Gosselink R (2009) Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 37(9):2499–2505.  https://doi.org/10.1097/CCM.0b013e3181a38937 CrossRefPubMedGoogle Scholar
  49. 49.
    Morris JH, Chen L (2019) Exercise training and heart failure: a review of the literature. Cardiac Fail Rev 5(1):57–61.  https://doi.org/10.15420/cfr.2018.31.1 CrossRefGoogle Scholar
  50. 50.
    Mudge AM, Denaro CP, Scott AC, Meyers D, Adsett JA, Mullins RW, Suna JM, Atherton JJ, Marwick TH, Scuffham P, O'Rourke P (2018) Addition of supervised exercise training to a post-hospital disease management program for patients recently hospitalized with acute heart failure: the EJECTION-HF randomized phase 4 trial. JACC Heart Fail 6(2):143–152.  https://doi.org/10.1016/j.jchf.2017.11.016 CrossRefPubMedGoogle Scholar
  51. 51.
    Oliveira MF, Santos RC, Artz SA, Mendez VMF, Lobo DML, Correia EB, Ferraz AS, Umeda IIK, Sperandio PA (2018) Safety and efficacy of aerobic exercise training associated to non-invasive ventilation in patients with acute heart failure. Arq Bras Cardiol 110(5):467–475.  https://doi.org/10.5935/abc.20180039 CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Scrutinio D, Passantino A, Catanzaro R, Farinola G, Lagioia R, Mastropasqua F, Ricci A, Santoro D (2012) Inpatient cardiac rehabilitation soon after hospitalization for acute decompensated heart failure: a propensity score study. J Cardiopulm Rehabil Prev 32(2):71–77.  https://doi.org/10.1097/HCR.0b013e31823be124 CrossRefPubMedGoogle Scholar
  53. 53.
    Tanaka S, Kamiya K, Matsue Y, Yonezawa R, Saito H, Hamazaki N, Matsuzawa R, Nozaki K, Wakaume K, Endo Y, Maekawa E, Yamaoka-Tojo M, Shiono T, Inomata T, Masuda T, Ako J (2017) Effects of acute phase intensive electrical muscle stimulation in frail elderly patients with acute heart failure (ACTIVE-EMS): rationale and protocol for a multicenter randomized controlled trial. Clin Cardiol 40(12):1189–1196.  https://doi.org/10.1002/clc.22845 CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Forestieri P, Bolzan DW, Santos VB, Moreira RSL, de Almeida DR, Trimer R, de Souza BF, Borghi-Silva A, de Camargo Carvalho AC, Arena R, Gomes WJ, Guizilini S (2018) Neuromuscular electrical stimulation improves exercise tolerance in patients with advanced heart failure on continuous intravenous inotropic support use-randomized controlled trial. Clin Rehabil 32(1):66–74.  https://doi.org/10.1177/0269215517715762 CrossRefPubMedGoogle Scholar
  55. 55.
    Groehs RV, Antunes-Correa LM, Nobre TS, Alves MJ, Rondon MU, Barreto AC, Negrao CE (2016) Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients. Eur J Prev Cardiol 23(15):1599–1608.  https://doi.org/10.1177/2047487316654025 CrossRefPubMedGoogle Scholar
  56. 56.
    Tanaka S, Masuda T, Kamiya K, Hamazaki N, Akiyama A, Kamada Y, Maekawa E, Noda C, Yamaoka-Tojo M, Ako J (2016) A single session of neuromuscular electrical stimulation enhances vascular endothelial function and peripheral blood circulation in patients with acute myocardial infarction. Int Heart J 57(6):676–681.  https://doi.org/10.1536/ihj.15-493 CrossRefPubMedGoogle Scholar
  57. 57.
    Gomes Neto M, Oliveira FA, Reis HF, de Sousa Rodrigues E Jr, Bittencourt HS, Oliveira Carvalho V (2016) Effects of neuromuscular electrical stimulation on physiologic and functional measurements in patients with heart failure: a systematic review with meta-analysis. J Cardiopulm Rehabil Prev 36(3):157–166.  https://doi.org/10.1097/hcr.0000000000000151 CrossRefPubMedGoogle Scholar
  58. 58.
    Ploesteanu RL, Nechita AC, Turcu D, Manolescu BN, Stamate SC, Berteanu M (2018) Effects of neuromuscular electrical stimulation in patients with heart failure - review. J Med Life 11(2):107–118PubMedPubMedCentralGoogle Scholar
  59. 59.
    Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJ (2015) Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (London, England : 1979) 128(6):357–365.  https://doi.org/10.1042/cs20140447 CrossRefGoogle Scholar
  60. 60.
    Fleg JL, Cooper LS, Borlaug BA, Haykowsky MJ, Kraus WE, Levine BD, Pfeffer MA, Piña IL, Poole DC, Reeves GR, Whellan DJ, Kitzman DW (2015) Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail 8(1):209–220.  https://doi.org/10.1161/circheartfailure.113.001420 CrossRefPubMedPubMedCentralGoogle Scholar
  61. 61.
    Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, Bellomo R, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, Hillege H, House AA, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P (2010) Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J 31(6):703–711.  https://doi.org/10.1093/eurheartj/ehp507 CrossRefGoogle Scholar
  62. 62.
    Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, Young JB, Tang WH (2009) Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 53(7):589–596.  https://doi.org/10.1016/j.jacc.2008.05.068 CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Dupont M, Mullens W, Tang WH (2011) Impact of systemic venous congestion in heart failure. Curr Heart Fail Rep 8(4):233–241.  https://doi.org/10.1007/s11897-011-0071-7 CrossRefPubMedGoogle Scholar
  64. 64.
    Marik PE, Baram M, Vahid B (2008) Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 134(1):172–178.  https://doi.org/10.1378/chest.07-2331 CrossRefPubMedGoogle Scholar
  65. 65.
    Costanzo MR, Guglin ME, Saltzberg MT, Jessup ML, Bart BA, Teerlink JR, Jaski BE, Fang JC, Feller ED, Haas GJ, Anderson AS, Schollmeyer MP, Sobotka PA (2007) Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol 49(6):675–683.  https://doi.org/10.1016/j.jacc.2006.07.073 CrossRefPubMedGoogle Scholar
  66. 66.
    Mullens W, Abrahams Z, Skouri HN, Francis GS, Taylor DO, Starling RC, Paganini E, Tang WH (2008) Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function? J Am Coll Cardiol 51(3):300–306.  https://doi.org/10.1016/j.jacc.2007.09.043 CrossRefPubMedGoogle Scholar
  67. 67.
    Viswanathan G, Gilbert S (2011) The cardiorenal syndrome: making the connection. Int J Nephrol 2011:283137–283110.  https://doi.org/10.4061/2011/283137 CrossRefGoogle Scholar
  68. 68.
    Cops J, Haesen S, De Moor B, Mullens W, Hansen D (2019) Current animal models for the study of congestion in heart failure: an overview. Heart Fail Rev 24:387–397.  https://doi.org/10.1007/s10741-018-9762-4 CrossRefPubMedPubMedCentralGoogle Scholar
  69. 69.
    Colombo PC, Jorde UP (2010) The active role of venous congestion in the pathophysiology of acute decompensated heart failure. Rev Esp Cardiol (Engl Ed) 63(01):5–8CrossRefGoogle Scholar
  70. 70.
    Ambrosy AP, Mulder H, Coles A, Krauss WE, Lam CSP, McCullough PA, Pina I, Tromp J, Whellan DJ, O’Connor CM, Mentz RJ (2018) Renal function and exercise training in ambulatoryheart failure patients with a reduced ejection fraction. Am J Cardiol 122(6):999–1007.  https://doi.org/10.1016/j.amjcard.2018.06.011 CrossRefPubMedGoogle Scholar
  71. 71.
    Hama T, Oikawa K, Ushijima A, Morita N, Matsukage T, Ikari YJ, Kobayashi Y (2018) Effect of cardiac rehabilitation on the renal function in chronic kidney disease - analysis using serum cystatin-C based glomerular filtration rate. Int J Cardiol Heart Vasculature 19:27–33.  https://doi.org/10.1016/j.ijcha.2018.04.001 CrossRefGoogle Scholar
  72. 72.
    Nijst P, Mullens W (2014) The acute cardiorenal syndrome: burden and mechanisms of disease. Curr Heart Fail Rep 11(4):453–462.  https://doi.org/10.1007/s11897-014-0218-4 CrossRefPubMedGoogle Scholar
  73. 73.
    Afsar B, Ortiz A, Covic A, Solak Y, Goldsmith D, Kanbay M (2016) Focus on renal congestion in heart failure. Clin Kidney J 9(1):39–47.  https://doi.org/10.1093/ckj/sfv124 CrossRefPubMedGoogle Scholar
  74. 74.
    Tang WH, Mullens W (2010) Cardiorenal syndrome in decompensated heart failure. Heart 96(4):255–260.  https://doi.org/10.1136/hrt.2009.166256 CrossRefPubMedGoogle Scholar
  75. 75.
    Zheng H, Li YF, Zucker IH, Patel KP (2006) Exercise training improves renal excretory responses to acute volume expansion in rats with heart failure. Am J Physiol Ren Physiol 291(6):F1148–F1156.  https://doi.org/10.1152/ajprenal.00501.2005 CrossRefGoogle Scholar
  76. 76.
    Marcus NJ, Pügge C, Mediratta J, Schiller AM, Del Rio R, Zucker IH, Schultz HD (2015) Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure. Am J Phys Heart Circ Phys 309(2):H259–H266.  https://doi.org/10.1152/ajpheart.00268.2015 CrossRefGoogle Scholar
  77. 77.
    Ikeda T, Gomi T, Sasaki Y (1994) Effects of swim training on blood pressure, catecholamines and prostaglandins in spontaneously hypertensive rats. Jpn Heart J 35(2):205–211CrossRefGoogle Scholar
  78. 78.
    Braith RW, Welsch MA, Feigenbaum MS, Kluess HA, Pepine CJ (1999) Neuroendocrine activation in heart failure is modified by endurance exercise training. J Am Coll Cardiol 34(4):1170–1175CrossRefGoogle Scholar
  79. 79.
    de Souza PS, da Rocha LG, Tromm CB, Scheffer DL, Victor EG, da Silveira PC, de Souza CT, Silva LA, Pinho RA (2012) Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease. Life Sci 91(3–4):132–136.  https://doi.org/10.1016/j.lfs.2012.06.028 CrossRefPubMedGoogle Scholar
  80. 80.
    Agarwal D, Elks CM, Reed SD, Mariappan N, Majid DS, Francis J (2012) Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats. Antioxid Redox Signal 16(2):139–152.  https://doi.org/10.1089/ars.2011.3967 CrossRefPubMedPubMedCentralGoogle Scholar
  81. 81.
    Peng CC, Chen KC, Hsieh CL, Peng RY (2012) Swimming exercise prevents fibrogenesis in chronic kidney disease by inhibiting the myofibroblast transdifferentiation. PLoS One 7(6):e37388.  https://doi.org/10.1371/journal.pone.0037388 CrossRefPubMedPubMedCentralGoogle Scholar
  82. 82.
    Chen KC, Peng CC, Hsieh CL, Peng RY (2013) Exercise ameliorates renal cell apoptosis in chronic kidney disease by intervening in the intrinsic and the extrinsic apoptotic pathways in a rat model. Evid Based Complement Alternat Med 2013:368450–368413.  https://doi.org/10.1155/2013/368450 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.BIOMED – Biomedical Research Institute, Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium
  2. 2.Doctoral School for Medicine and Life SciencesHasselt UniversityDiepenbeekBelgium
  3. 3.Department of NephrologyJessa ZiekenhuisHasseltBelgium
  4. 4.Department of CardiologyZiekenhuis Oost-LimburgGenkBelgium
  5. 5.REVAL – Rehabilitation Research Center, Faculty of Rehabilitation SciencesHasselt UniversityDiepenbeekBelgium
  6. 6.Heart Centre HasseltJessa ZiekenhuisHasseltBelgium

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