Heart Failure Reviews

, Volume 23, Issue 3, pp 409–418 | Cite as

SGLT2 inhibition and heart failure—current concepts

  • Joaquim Silva CustodioJrEmail author
  • Andre Rodrigues Duraes
  • Marconi Abreu
  • Natalia Albuquerque Rocha
  • Leonardo Roever


Type 2 diabetes mellitus (T2DM) is a major risk factor for several cardiovascular (CV) conditions, including heart failure (HF). However, until recently, no therapy to treat patients with diabetes could also reduce CV risks related to HF. The EMPA-REG OUTCOME trial with empagliflozin was the first to demonstrate significant cardioprotective benefits in this population. Its impressive 35% reduction in hospitalizations for HF drew the attention of the scientific community to the possibility that pharmacologic sodium-glucose cotransporter 2 (SGLT2) inhibition could be part of the armamentarium for treating patients with HF, with and without diabetes. The recently published CANVAS Program (with canagliflozin) and real-life data from the CVD-Real Study (using dapagliflozin, empagliflozin, and canagliflozin) further strengthened this hypothesis, suggesting that the observed benefit is not restricted to a particular drug, but is rather a class effect. This review explores the effects of pharmacologic SGLT2 inhibitors’ use in cardiac function and discusses the potential role of this class of medication as a treatment for HF.


SGLT2 inhibitors Diabetes mellitus Heart failure Cardiovascular outcomes 


Compliance with ethical standards

Conflict of interest

J.S. Custodio Jr. has received lecture fees from AstraZeneca, Boehringer Ingelheim, Janssen, and Eli Lilly. A.R. Duraes, M. Abreu, N. Albuquerque Rocha, and L. Roever have no conflicts of interest to disclose.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Joaquim Silva CustodioJr
    • 1
    • 2
    Email author
  • Andre Rodrigues Duraes
    • 1
    • 3
  • Marconi Abreu
    • 4
  • Natalia Albuquerque Rocha
    • 4
  • Leonardo Roever
    • 5
  1. 1.Department of Health Family, Medical School of BahiaFederal University of BahiaSalvadorBrazil
  2. 2.Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science InstituteFederal University of BahiaSalvadorBrazil
  3. 3.Roberto Santos General Hospital – SESABSalvadorBrazil
  4. 4.Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA
  5. 5.Department of Clinical ResearchFederal University of UberlandiaUberlândiaBrazil

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