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Effect of continuous positive airway pressure treatment on pulmonary artery pressure in patients with isolated obstructive sleep apnea: a meta-analysis

Heart Failure Reviews volume 21, pages 591–598 (2016)Cite this article

Abstract

Pulmonary hypertension (PH) can occur in patients with obstructive sleep apnea (OSA) in the absence of cardiac or lung disease. Data on the development and severity of PH, and the effect of continuous positive airway pressure (CPAP) therapy on pulmonary artery (PA) pressures in these patients have been inconsistent in the literature. We sought to determine whether CPAP therapy affects PA pressures in patients with isolated OSA in this meta-analysis. We searched PubMed, Medline, EMBASE and other databases from January 1980 to August 2015. Studies of patients with OSA, defined as an apnea–hypopnea index >10 events/h, and PH, defined as PA pressure >25 mmHg were included. Two reviewers independently extracted data and assessed risk of bias. A total of 222 patients from seven studies (341.53 person-years) had reported PA pressures before and after treatment with CPAP therapy. 77 % of participants were men, with a mean age of 52.5 years, a mean apnea–hypopnea index of 58 events/h, and mean PA pressure of 39.3 ± 6.3 mmHg. CPAP treatment duration ranged from 3 to 70 months. Using fixed effects meta-analysis, CPAP therapy was associated with a decrease in PA pressure of 13.3 mmHg (95 % CI 12.7–14.0) in our study population. This meta-analysis found that CPAP therapy is associated with a significantly lower PA pressure in patients with isolated OSA and PH.

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No funding was received for this study.

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Authors and Affiliations

  1. Department of Medicine, Brigham & Women’s Hospital, VA Boston Healthcare System, Harvard Medical School, 1620 Tremont St, Boston, MA, 02120, USA

    Tasnim F. Imran, J. Michael Gaziano & Luc Djoussé

  2. Department of Population Health, New York University Langone Medical Center, 650 First Avenue, New York, NY, 10001, USA

    Marya Ghazipura

  3. Heart Failure and Pulmonary Hypertension Program, Rutgers, New Jersey Medical School, 30 Prospect St, Hackensack, NJ, 07103, USA

    Spencer Liu, Tanzib Hossain, Hormoz Ashtyani & Bernard Kim

Authors
  1. Tasnim F. Imran
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  2. Marya Ghazipura
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  3. Spencer Liu
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  5. Hormoz Ashtyani
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Correspondence to Tasnim F. Imran.

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Dr. Ashtyani has served as an expert witness regarding pulmonary hypertension. All other authors declare no conflict of interest.

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Imran, T.F., Ghazipura, M., Liu, S. et al. Effect of continuous positive airway pressure treatment on pulmonary artery pressure in patients with isolated obstructive sleep apnea: a meta-analysis. Heart Fail Rev 21, 591–598 (2016). https://doi.org/10.1007/s10741-016-9548-5

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  • DOI: https://doi.org/10.1007/s10741-016-9548-5

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