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RV diastolic dysfunction: time to re-evaluate its importance in heart failure

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Abstract

Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the structure and function of the RV make the detailed assessment of the contractile performance challenging when compared to its left ventricular (LV) counterpart. LV dysfunction is known to directly affect patient outcome in heart failure. As such, the focus has therefore been on LV function. Nevertheless, a strategy for the diagnosis and assessment of RV diastolic dysfunction has not been established. Here, we review the different causal mechanisms underlying RV diastolic dysfunction, summarising the current assessment techniques used in a clinical environment. Finally, we explore the role of load-independent indices of RV contractility, derived from the conductance technique, to fully interrogate the RV and expand our knowledge and understanding of RV diastolic dysfunction. Accurate assessment of RV contractility may yield further important prognostic information that will benefit patients with diastolic heart failure.

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Acknowledgments

Mr Richard Axell is funded by a National Institute for Health Research Chief Scientific Officer Healthcare Scientist Doctoral Fellowship Grant (NIHR-HCS-D12-14). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

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Authors and Affiliations

  1. Medical Physics and Clinical Engineering, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK

    Richard G. Axell & Paul A. White

  2. Postgraduate Medical Institute, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, Essex, CM1 1SQ, UK

    Richard G. Axell, James Hampton-Till & Paul A. White

  3. Department of Cardiology, Papworth Hospital NHS Foundation Trust, Cambridge, CB23 3RE, UK

    Stephen P. Hoole

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  1. Richard G. Axell
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  2. Stephen P. Hoole
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  3. James Hampton-Till
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  4. Paul A. White
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Correspondence to Richard G. Axell or Paul A. White.

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Axell, R.G., Hoole, S.P., Hampton-Till, J. et al. RV diastolic dysfunction: time to re-evaluate its importance in heart failure. Heart Fail Rev 20, 363–373 (2015). https://doi.org/10.1007/s10741-015-9472-0

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