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Calcium handling proteins: structure, function, and modulation by exercise

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Abstract

Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation–contraction process in the heart among those are sarcoplasmic reticulum Ca2+-ATPase, phospholamban, calsequestrin, sodium–calcium exchanger, L-type calcium’s channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.

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Acknowledgments

Research supported by FAPEMIG-RedeToxifar, CNPq, INCT-FAPEMIG-CNPq, Pronex Project Grant (FAPEMIG/CNPq), and CAPES. Agradecimento ao Prof. Dr. Paulo Bastista de Carvalho, membro do corpo docente da Notre Dame Catholic University of Baltimore, pela colaboração ao longo desse trabalho.

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  1. Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Prêto, Brazil

    Jamille Locatelli, Leonardo V. M. de Assis & Mauro C. Isoldi

  2. Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Ouro Prêto, MG, 35400-000, Brazil

    Jamille Locatelli, Leonardo V. M. de Assis & Mauro C. Isoldi

  3. Departamento de Ciências Biológicas, DECBI-NUPEB, Universidade Federal de Ouro Preto (UFOP), Ouro Prêto, MG, Brazil

    Mauro C. Isoldi

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Locatelli, J., de Assis, L.V.M. & Isoldi, M.C. Calcium handling proteins: structure, function, and modulation by exercise. Heart Fail Rev 19, 207–225 (2014). https://doi.org/10.1007/s10741-013-9373-z

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