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Resveratrol and red wine, healthy heart and longevity

Heart Failure Reviews volume 15, pages 467–477 (2010)Cite this article

An Erratum to this article was published on 13 March 2011

Abstract

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

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Abbreviations

SIRT:

Sirtuins.

FoxO:

Forkhead transcription factor.

PBEF:

Pre B cell colony enhancing factor.

LDL:

Low-density lipoprotein.

BMR:

Basal metabolic rate.

CR:

Calorie restriction.

IGF1:

Insulin-dependent growth factor 1

ROS:

Reactive oxygen species

NOS:

Nitric oxide synthase

VEGF:

Vascular endothelial growth factor

GLUT:

Glucose transporter type 4

PUFA:

Polyunsaturated fatty acids

HO-1:

Heme oxygenase-1

PKC:

Protein kinase C

PI3 kinase:

Phosphatidylinositol-3-kinase

LPS:

Lipopolysaccharide

PGE2:

Prostaglandin E2

TNFα:

Tumor necrosis factor α

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Acknowledgements

This study was supported by NH HL 34360, HL22559 and HL33889.

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Authors and Affiliations

  1. Cardiovacular Research Center, University of Connecticut School of Medicine, Farmington, CT, 06030-1110, USA

    Dipak K. Das, Subhendu Mukherjee & Diptarka Ray

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  1. Dipak K. Das
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  2. Subhendu Mukherjee
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  3. Diptarka Ray
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Correspondence to Dipak K. Das.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10741-011-9234-6

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Das, D.K., Mukherjee, S. & Ray, D. Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 15, 467–477 (2010). https://doi.org/10.1007/s10741-010-9163-9

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Keywords

  • Resveratrol
  • Red wine
  • White wine
  • Cardioprotection
  • Longevity genes
  • Anti-aging
  • SIRT
  • FoxO
  • PBEF