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Resveratrol and red wine, healthy heart and longevity

An Erratum to this article was published on 13 March 2011

Abstract

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

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Abbreviations

SIRT:

Sirtuins.

FoxO:

Forkhead transcription factor.

PBEF:

Pre B cell colony enhancing factor.

LDL:

Low-density lipoprotein.

BMR:

Basal metabolic rate.

CR:

Calorie restriction.

IGF1:

Insulin-dependent growth factor 1

ROS:

Reactive oxygen species

NOS:

Nitric oxide synthase

VEGF:

Vascular endothelial growth factor

GLUT:

Glucose transporter type 4

PUFA:

Polyunsaturated fatty acids

HO-1:

Heme oxygenase-1

PKC:

Protein kinase C

PI3 kinase:

Phosphatidylinositol-3-kinase

LPS:

Lipopolysaccharide

PGE2:

Prostaglandin E2

TNFα:

Tumor necrosis factor α

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Acknowledgements

This study was supported by NH HL 34360, HL22559 and HL33889.

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Correspondence to Dipak K. Das.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10741-011-9234-6

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Das, D.K., Mukherjee, S. & Ray, D. Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 15, 467–477 (2010). https://doi.org/10.1007/s10741-010-9163-9

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Keywords

  • Resveratrol
  • Red wine
  • White wine
  • Cardioprotection
  • Longevity genes
  • Anti-aging
  • SIRT
  • FoxO
  • PBEF