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Protection of the abnormal heart

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Abstract

Myocardial ischemia and reperfusion injury have been extensively investigated in the laboratory mainly in healthy tissues. However, in clinical settings, ischemic heart disease coexists with certain illnesses, which could potentially influence the response of the myocardium to ischemia and reperfusion. Recent research has revealed that the abnormal heart may not be always vulnerable to ischemic injury. Furthermore, the effect of powerful means of protection, such as ischemic preconditioning, may not be in operation under certain pathological conditions. With this evidence in mind, the present review will focus on the response of the abnormal heart to ischemia and reperfusion, the possible underlying mechanisms, and potential cardioprotective strategies.

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Authors and Affiliations

  1. Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., 11527, Goudi, Athens, Greece

    Constantinos Pantos & Iordanis Mourouzis

  2. 1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave., 17674, Kallithea, Athens, Greece

    Dennis V. Cokkinos

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  1. Constantinos Pantos
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  2. Iordanis Mourouzis
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  3. Dennis V. Cokkinos
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Correspondence to Constantinos Pantos.

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Pantos, C., Mourouzis, I. & Cokkinos, D.V. Protection of the abnormal heart. Heart Fail Rev 12, 319–330 (2007). https://doi.org/10.1007/s10741-007-9036-z

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