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The late phase of preconditioning and its natural clinical application—gene therapy

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Abstract

There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC for the development of novel gene therapy strategies aimed at inducing a permanently preconditioned cardiac phenotype (prophylactic cardioprotection) will also be discussed. Deciphering the mechanism of late PC has not only conceptual interest but also a considerable therapeutic implications, since transfer of the genes that underlie late PC would be expected to replicate the salubrious effects of this response of the heart to stress.

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Acknowledgments

This study was supported in part by NIH R01 grants HL-55757, HL-68088, HL-70897, HL-76794, HL-78825, and HL-74351.

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Authors and Affiliations

  1. Division of Cardiology, University of Louisville, 550 S. Jackson St., ACB, 3rd floor, Louisville, KY, 40292, USA

    Roberto Bolli, Qian-Hong Li, Xian-Liang Tang, Yiru Guo, Yu-Ting Xuan, Gregg Rokosh & Buddhadeb Dawn

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  1. Roberto Bolli
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  2. Qian-Hong Li
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Correspondence to Roberto Bolli.

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Bolli, R., Li, QH., Tang, XL. et al. The late phase of preconditioning and its natural clinical application—gene therapy. Heart Fail Rev 12, 189–199 (2007). https://doi.org/10.1007/s10741-007-9031-4

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