Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated
- 298 Downloads
CBLL1 (Casitas B-lineage lymphoma-transforming sequence-like protein 1) also known as Hakai, was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex. Recent data have provided evidences for novel biological functional role of CBLL1 during tumor progression and other diseases. However, its distribution and function in the central nervous system (CNS) remains unclear. In this study, we found CBLL1 was significant up-regulation in cerebral cortex after LPS administration and immunofluorescent labeling indicated that CBLL1 was localized striking in the neurons. We also investigated co-staining of CBLL1 and active-caspase-3 and cyclin D1 in the cerebral cortex following LPS administration. Based on our data, we speculated that CBLL1 might play an important role in neuronal apoptosis following LPS administration and might provide a basis for the further study on its role in cell cycle re-entry in neuroinflammation in CNS.
KeywordsCBLL1 Lipopolysaccharide Apoptosis Rat
This study was supported by the National Natural Science Foundation of China (No. 21077061) and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
- Nimmervoll B, White R, Yang JW, An S, Henn C, Sun JJ, Luhmann HJ (2012) LPS-induced microglial secretion of TNFalpha increases activity-dependent neuronal apoptosis in the neonatal cerebral cortex. Cereb Cortex. doi: 10.1093/cercor/bhs156
- Wu X, Li J, Chen C, Yan Y, Jiang S, Shao B, Xu J, Kang L, Huang Y, Zhu L et al (2012) Involvement of CLEC16A in activation of astrocytes after LPS treated. Neurochem Res 37:5–14Google Scholar