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Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study

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Abstract

Central Giant Cell Lesion (CGCL) is an uncommon benign jaw lesion, with uncertain etiology, and a variable clinical behavior. Studies of molecular markers of CGCL, may help understanding better the nature and behavior of this lesion, and eventually may represent a definitive target to pharmacological approach in the treatment of CGCL. Chronic inflammation has been found to mediate a wide variety of diseases including neoplasms. Among the gene products involved in the induction of the inflammatory process, Cyclooxygenase 2 (COX-2) has been shown to have a close relationship with tumorigenesis, however COX-2 expression has never been evaluated in CGCL. The aim of the study was to investigate the expression of COX-2 in CGCL. Immunohistochemical assessment for COX-2 expression was performed in 18 patients previously diagnosed with CGCL. Multinucleated giant cells (MGC) and mononucleated stromal cells (MSC) were used in the slide analysis. Among the patients studied, 10 were male and 8 were female, with a median age of 15.4 years. Lesions in the mandible were observed in 11 cases and 7 were found in the maxilla. There were 9 aggressive and 9 non-aggressive CGCLs. COX-2 immunopositivity was present in only 3 cases stained in both MGC and MSC. All 3 cases presented with ulcerations in the mucosa lesion, suggesting that the COX-2 expression is due to the presence of inflammation. This study does not support the involvement of COX-2 in the etiophatogenesis of CGCL.

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Dental Clinic, Discipline of Oral and Maxillofacial Surgery and Stomatology, Federal University of Ceará School of Dentistry, Dom Luiz 1200, Torre I, Sala 410, Aldeota, Fortaleza, Ceará, Brazil

    Renato Luiz Maia Nogueira

  2. Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Memorial Batista Hospital, Dom Luiz 1200, Torre I, Sala 410, Aldeota, Fortaleza, Brazil

    Renato Luiz Maia Nogueira

  3. Molecular Genetics Laboratory, LABGEM, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Brazil

    Mário Henrique Girão Faria

  4. Department of Pathology, Fortaleza University School of Medicine, Fortaleza, Brazil

    Rafael Lima Verde Osterne

  5. Department of Oral and Maxillofacial Pathology, Fortaleza University School of Dentistry, Fortaleza, Brazil

    Roberta Barroso Cavalcante

  6. Department of Physiology and Pharmacology, Federal University of Ceara School of Medicine, Fortaleza, Brazil

    Ronaldo Albuquerque Ribeiro

  7. Molecular Genetics Laboratory, LABGEM, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Brazil

    Silvia Helena Barem Rabenhorst

Authors
  1. Renato Luiz Maia Nogueira
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  2. Mário Henrique Girão Faria
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  3. Rafael Lima Verde Osterne
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  4. Roberta Barroso Cavalcante
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  5. Ronaldo Albuquerque Ribeiro
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  6. Silvia Helena Barem Rabenhorst
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Correspondence to Renato Luiz Maia Nogueira.

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Nogueira, R.L.M., Faria, M.H.G., Osterne, R.L.V. et al. Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study. J Mol Hist 43, 59–62 (2012). https://doi.org/10.1007/s10735-011-9369-8

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  • DOI: https://doi.org/10.1007/s10735-011-9369-8

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