Journal of Molecular Histology

, Volume 39, Issue 4, pp 359–370

Expression of the ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation

Original Paper

DOI: 10.1007/s10735-008-9174-1

Cite this article as:
Kirschke, C.P. & Huang, L. J Mol Hist (2008) 39: 359. doi:10.1007/s10735-008-9174-1


A prostate contains ~10-fold higher zinc than other soft organs. The function of the prostate is to produce a zinc-enriched seminal fluid. To establish a protein expression profile for zinc transporters involved in zinc efflux and intracellular sequestration/storage in the mouse prostate during sexual maturation, ZNT expression were investigated by immunohistochemistry. Our study demonstrated that ZNT proteins were differentially expressed in the prostate during sexual maturation. ZNT1 was mainly detected on the lateral membrane of the epithelium. Other ZNTs examined resided intracellularly. Among differences were a staining of ZNT2/ZNT5 in the ER-rich area of the epithelium in the anterior lobe, a staining of ZNT2 along the lateral and apical membrane, a luminal border staining of ZNT4, a staining of ZNT5 in the Golgi area of the epithelium in the ventral lobe, a uniform expression of ZNT6 across the lobes and ages, and a staining of ZNT7 in all lobes across ages.


Zinc transporters Slc30 family ZNT Mouse prostate Male genital tract Cellular zinc accumulation 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.USDA, ARSWestern Human Nutrition Research Center, UC DavisDavisUSA
  2. 2.Department of Nutrition and Rowe Program in GeneticsUniversity of California DavisDavisUSA

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