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Spatio-temporal specification of olfactory bulb interneurons

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Abstract

Olfactory bulb (OB) interneurons are continuously generated throughout development and in adulthood, and are derived from different progenitor zones. Once integrated in the OB circuits, interneurons play essential roles in olfactory information processing by modulating the activity of major output neurons. These functions are performed by multiple classes of neurons that differ in their spatial distribution, morphology, neurochemical and synaptic properties. This diversity, and the continuous neurogenesis make the understanding of the specification mechanisms in the OB a challenging task. New studies suggest that both intrinsic and extrinsic cues are involved in fate determination of OB interneurons. In both development and adulthood the expression of specific transcription factors not only defines different progenitor regions but also precise interneuronal phenotypes. Here we discuss recent findings on the molecular mechanisms regulating production and diversity of OB interneurons with respect to the spatial and temporal parameters.

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Acknowledgements

Supports Contributed by: Compagnia di San Paolo (Neurotransplant 2004.2019), Regione Piemonte Ricerca Scientifica Applicata (CIPE, proj. nr. A14) and PRIN 2005 (proj.nr 2005055095)

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  1. Department of Animal and Human Biology, University of Turin, Via Accademia Albertina 13, Turin, 10123, Italy

    Serena Bovetti, Paolo Peretto, Aldo Fasolo & Silvia De Marchis

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  1. Serena Bovetti
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  2. Paolo Peretto
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  4. Silvia De Marchis
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Correspondence to Silvia De Marchis.

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Bovetti, S., Peretto, P., Fasolo, A. et al. Spatio-temporal specification of olfactory bulb interneurons. J Mol Hist 38, 563–569 (2007). https://doi.org/10.1007/s10735-007-9111-8

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