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Magmas expression in neoplastic human prostate

Journal of Molecular Histology volume 36, pages 69–75 (2005)Cite this article

Abstract

Magmas, is a 13-kDa mitochondrial protein which is ubiquitously expressed in eukaryotic cells. It was identified as a granulocyte-macrophage-colony stimulating factor (GM-CSF) inducible gene in hematopoietic cells and has a key role in the transport of mitochondrial proteins in yeast. Because GM-CSF receptor levels are elevated in prostate cancer, Magmas expression was examined in normal and neoplastic tissue. Magmas protein levels were barely detectible in non-neoplastic prostate glands. Increased amounts were observed in some samples of intraepithelial neoplasia. Approximately one half of the adenocarcinoma samples examined had weak Magmas expression, while the remainder had intermediate to high levels. The increased Magmas observed in malignant tissue was a result of higher protein expression and not from changes in mitochondrial content. Interestingly, in some patients, the normal prostate tissue had more Magmas message than the malignant portion. The results indicated that Magmas expression in prostate cancer is heterogeneous and independent of clinical stage and Gleason score. Further studies are needed to determine if Magmas expression has prognostic significance in prostate cancer.

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Affiliations

  1. Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, Bronx, NY, USA

    Paul T. Jubinsky & Mary K. Short

  2. Department of Pathology, University of Cincinnati School of Medicine, Cincinnati, OH, USA

    George Mutema

  3. Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati School of Medicine, USA

    Randal E. Morris & Georgianne M. Ciraolo

  4. Department of Pathology, Montefiore Medical Center, Bronx, NY, USA

    Maomi Li

Authors
  1. Paul T. Jubinsky
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  2. Mary K. Short
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  3. George Mutema
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  4. Randal E. Morris
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  5. Georgianne M. Ciraolo
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  6. Maomi Li
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Correspondence to Paul T. Jubinsky.

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Jubinsky, P.T., Short, M.K., Mutema, G. et al. Magmas expression in neoplastic human prostate. J Mol Hist 36, 69–75 (2005). https://doi.org/10.1007/s10735-004-3840-8

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  • DOI: https://doi.org/10.1007/s10735-004-3840-8

Keywords

  • Prostate Cancer
  • Gleason Score
  • Mitochondrial Protein
  • Human Prostate
  • Inducible Gene