Will Artificial Gametes End Infertility?

Abstract

In this paper we will look at the various ways in which infertility can be understood and at how need for reproductive therapies can be construed. We will do this against the background of research with artificial gametes (AGs). Having explored these questions we will attempt to establish the degree to which technologies such as AGs could expand the array of choices that people have to reproduce and/or become parents. Finally, we will examine whether and in what ways the most promising developments of such technologies are likely to bring about the “end of infertility”.

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References

  1. 1.

    Barritt, J. A., Brenner, C. A., Malter, H. E., & Cohen, J. (2001). Mitochondria in human offspring derived from ooplasmic transplantation. Human Reproduction, 16(3), 513–516.

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Bateman, S. (2002). When reproductive freedom encounters medical responsibility: Changing conceptions of reproductive choice. In E. Vayena, P. J. Rowe, & P. D. Griffin (Eds.), Current practices and controversies in assisted reproduction: Report of a WHO meeting (pp. 320–332). Geneva: World Health Organization.

    Google Scholar 

  3. 3.

    BBC News Online. (10th April 2007). Woman loses final embryo appeal. Available at http://news.bbc.co.uk/1/hi/health/6530295.stm. Accessed Oct 2013.

  4. 4.

    BBC News Online. (2nd August 2007). Ovarian transplant first welcomed. Available at http://news.bbc.co.uk/1/hi/health/6924014.stm. Accessed Oct 2013.

  5. 5.

    BBC News Online. (8th September 2005). Embryo with two mothers approved.

  6. 6.

    Bhattacharya, S. (24th July 2003). Stem cells can end infertility, say IVF pioneers. Available at http://www.newscientist.com/article/dn3980-stem-cells-can-end-infertility-say-ivf-pioneers.html. Accessed Oct 2013.

  7. 7.

    Brandes, M., Hamilton, C. J. C. M., van der Steen, J. O. M., de Bruin, J. P., Bots, R. S. G. M., Nelen, W. L. D. M., et al. (2010). Unexplained infertility: Overall ongoing pregnancy rate and mode of conception. Human Reproduction, 26(2), 360–368.

    Article  PubMed  Google Scholar 

  8. 8.

    Cutas, D. (2009). Sex is overrated: On the right to reproduce. Human Fertility, 12(1), 45–52.

    Google Scholar 

  9. 9.

    Deng, J. M., Satoh, K., Chang, H., Zhang, Z., Stewart, M. D., Wang, H., et al. (2011). Generation of viable male and female mice from two fathers. Biology of Reproduction, 84(3), 613–618.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. 10.

    Derbyshire, D. (17th Oct 2004) Scientists seeking to create embryos with three parents. The telegraph.

  11. 11.

    Douglas, T., Harding, C., Bourne, H., & Savulescu, J. (2012). Stem cell research and same-sex reproduction. In M. Quigley, S. Chan, & J. Harris (Eds.), Stem cells. New frontiers in science and ethics. New Jersey: World Scientific.

    Google Scholar 

  12. 12.

    ESHRE. (2013). The world’s number of IVF and ICSI babies has now reached a calculated total of 5 million. Available at http://www.eshre.eu/ESHRE/English/Press-Room/Press-Releases/Press-releases-2012/5-million-babies/page.aspx/1606. Accessed Oct 2013.

  13. 13.

    Franklin, S. (2007). Dolly mixtures: The remaking of genealogy. Durham: Duke University Press.

    Google Scholar 

  14. 14.

    Geijsen, N., Horoschak, M., Kim, K., Gribnau, J., Eggan, K., & Daley, G. Q. (2004). Derivation of embryonic germ cells and make gametes from embryonic stem cells. Nature, 427, 148–154.

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Gurnham, D. (2012). Donor-conception as a “dangerous supplement” to the nuclear family. What can we learn from parents’ stories? In D. Cutas & S. Chan (Eds.), Families—Beyond the nuclear ideal (pp. 84–109). London: Bloomsbury Academic.

    Google Scholar 

  16. 16.

    Gurunath, S., Pandian, Z., Anderson, R., & Bhattacharya, S. (2011). Defining infertility—a systematic review of prevalence studies. Human Reproduction Update, 17(5), 575–578.

    Article  CAS  PubMed  Google Scholar 

  17. 17.

    Habbema, J. D. F., Collins, J., Leridon, H., Evers, J. L., Lunenfeld, B., & te Velde, E. R. (2004). Towards less confusing terminology in reproductive medicine: A proposal. Fertility and Sterility, 82(1), 36–40.

    Article  PubMed  Google Scholar 

  18. 18.

    Harris, J. (1997). Goodbye Dolly? The ethics of human cloning. Journal of Medical Ethics, 23, 353–360.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. 19.

    Harris, J. (2003). Assisted reproductive technological blunders. Journal of Medical Ethics, 29, 205–206.

    Article  PubMed Central  PubMed  Google Scholar 

  20. 20.

    Heindrycks, B., De Sutter, P., Gerris, J., Dhont, M., & Van der Elst, J. (2007). Embryo development after successful somatic cell nuclear transfer to in vitro matured human germinal vesicle oocytes. Human Reproduction, 22(7), 1982–1990.

    Article  Google Scholar 

  21. 21.

    Hinxton Group. (2008). Consensus statement: Science, ethics and policy challenges of pluripotent stem cell-derived gametes. Available at http://www.hinxtongroup.org/au_pscdg_cs.html. Accessed Oct 2013.

  22. 22.

    Kerkis, I., Mendes, C. M., da Fonseca, S. A. S., Lizier, N. F., Serafim, R. C., & Kerkis, A. (2011). Actual achievements on germ cells and gametes derived from pluripotent stem cells. In C. Atwood (Ed.), Embryonic stem cells—Recent advances in pluripotent stem cell-based regenerative medicine (pp. 311–336). Rijeka: InTech.

    Google Scholar 

  23. 23.

    Kono, T., Obata, Y., Quiong, W., Katsutoshi, N., Yukiko, O., Yamamoto, Y., et al. (2004). Birth of parthenogenetic mice that can develop to adulthood. Nature, 428, 860–864.

    Article  CAS  PubMed  Google Scholar 

  24. 24.

    MacCallum, F. (2007). Parenting genetically unrelated children. In K. Horsey & H. Biggs (Eds.), Human fertilisation and embryology: Reproducing regulation. London: Routledge Cavendish.

    Google Scholar 

  25. 25.

    National Institute of Clinical Excellence. (2013). Fertility: Assessment and treatment for people with fertility problems. February 2013. Available at http://publications.nice.org.uk/fertility-cg156/key-priorities-for-implementation. Accessed Oct 2013.

  26. 26.

    Oakley, A. (1993). Technologies of procreation. In A. Oakley (Ed.), Essays on women, medicine and health (p. 177). Edinburgh: Edinburgh University Press.

    Google Scholar 

  27. 27.

    Robertson, J. A. (1994). Children of choice. Freedom and the new reproductive technologies. Princeton: Princeton University Press.

    Google Scholar 

  28. 28.

    Smajdor, A. (2008). Artificial gametes: The end of infertility? Bionews, 26 February 2008. Available at http://www.bionews.org.uk/page_37977.asp. Accessed Oct 2013.

  29. 29.

    Smajdor, A. (2008). Reproduction with artificial gametes: Ethical and regulatory concerns. PhD Thesis. Imperial College, London.

  30. 30.

    Testa, G., & Harris, J. (2005). Ethics and synthetic gametes. Bioethics, 19(2), 146–166.

    Article  PubMed  Google Scholar 

  31. 31.

    Van Geloven, N., Van der Veen, F., Bossuyt, P. M. M., Hompes, P. G., Zwinderman, A. H., & Mol, B. W. (2013). Can we distinguish between infertility and subfertility when predicting natural conception in couples with an unfulfilled child wish? Human Reproduction, 28(3), 658–666.

    Article  PubMed  Google Scholar 

  32. 32.

    White, Y. A. R., Woods, D. C., Takai, Y., Ishihara, O., Seki, H., & Tilly, J. (2012). Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nature Medicine, 18, 413–421.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. 33.

    World Health Organisation. WHA41.10. (16th May 1998). Ethical, scientific and social implications of cloning in human health. Available at: http://www.who.int/ethics/en/WHA51_10.pdf. Accessed Oct 2013.

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Correspondence to Daniela Cutas.

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Smajdor, A., Cutas, D. Will Artificial Gametes End Infertility?. Health Care Anal 23, 134–147 (2015). https://doi.org/10.1007/s10728-013-0268-x

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Keywords

  • Artificial gametes
  • ARTs
  • Eligibility for ARTs
  • Infertility
  • Medical need
  • Need of ARTs
  • Parenthood