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Pectin: Health-promoting properties as a natural galectin-3 inhibitor

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Abstract

Galectin-3 has a variety of important pathophysiological significance in the human body. Much evidence shows that the abnormal expression of galectin-3 is related to the formation and development of many diseases. Pectin is mostly obtained from processed citrus fruits and apples and is a known natural inhibitor of galactin-3. A large number of peels produced each year are discarded, and it is necessary to recycle some of the economically valuable active compounds in these by-products to reduce resource waste and environmental pollution. By binding with galectin-3, pectin can directly reduce the expression level of galectin-3 on the one hand, and regulate the expression level of cytokines by regulating certain signaling pathways on the other hand, to achieve the effect of treating diseases. This paper begins by presenting an overview of the basic structure of pectin, subsequently followed by a description of the structure of galectin-3 and its detrimental impact on human health when expressed abnormally. The health effects of pectin as a galectin-3 inhibitor were then summarized from the perspectives of anticancer, anti-inflammatory, ameliorating fibrotic diseases, and anti-diabetes. Finally, the challenges and prospects of future research on pectin are presented, which provide important references for expanding the application of pectin in the pharmaceutical industry or developing functional dietary supplements.

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Funding

This work was supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine. (No. ZYYCXTD-D-202005), the Key project at central government level (No. 2060302), National Natural Science Foundation of China (No. 81872956, 82173929), and Special Project for Transformation of Scientific and Technological Achievements in Qinghai Province (No. 2021-SF-150).

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  1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300193, China

    Lingzhuo An, Luyao Zhang, Pengwang Wang, Wenyuan Gao & Xia Li

  2. Key Laboratory of Modern Chinese Medicine Resources Research Enterprises, Tianjin, 300402, China

    Guanglu Chang

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An, L., Chang, G., Zhang, L. et al. Pectin: Health-promoting properties as a natural galectin-3 inhibitor. Glycoconj J (2024). https://doi.org/10.1007/s10719-024-10152-z

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