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Recent advances in understanding the roles of sialyltransferases in tumor angiogenesis and metastasis

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Abstract

Abnormal glycosylation is a common characteristic of cancer cells and there is a lot of evidence that glycans can regulate the biological behavior of tumor cells. Sialylation modification, a form of glycosylation modification, plays an important role in cell recognition, cell adhesion and cell signal transduction. Abnormal sialylation on the surface of tumor cells is related to tumor migration and invasion, with abnormal expression of sialyltransferases being one of the main causes of abnormal sialylation. Recent studies provide a better understanding of the importance of the sialyltransferases, and how they influences cancer cell angiogenesis, adhesion and Epithelial-Mesenchymal Transition (EMT). The present review will provide a direction for future studies in determining the roles of sialyltransferases in cancer metastasis, and abnormal sialyltransferases are likely to be potential biomarkers for cancer.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (31470799 and 31570953) and Special Fund of Dalian city for Distinguished Young Scholars (2017RJ07).

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  1. Chunyan Xu and Shidan Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Institute of Glycobiology, Dalian Medical University, No.9 West Section Lvshun South Road, Dalian, 116044, Liaoning Province, People’s Republic of China

    Chunyan Xu, Shidan Wang, Yinshuang Wu, Xiaoxin Sun & Shujing Wang

  2. Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning Province, People’s Republic of China

    Deyong Yang

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  1. Chunyan Xu
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Xu, C., Wang, S., Wu, Y. et al. Recent advances in understanding the roles of sialyltransferases in tumor angiogenesis and metastasis. Glycoconj J 38, 119–127 (2021). https://doi.org/10.1007/s10719-020-09967-3

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