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Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

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Abstract

Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

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Acknowledgments

The authors wish to sincerely thank all of the co-authors of the references cited in this review article. This research was supported in part by Scientific Research (B) (No. 23310153 and 26282212), Scientific Research on Innovative Areas “Chemical Biology of Natural Products” (No. 24102528 and 26102738), and Grants-in-Aid for Young Scientists (B) (No. 22710220) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT).

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The authors declare that they are free from conflict of interest.

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Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan

    Kazunobu Toshima & Daisuke Takahashi

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  1. Kazunobu Toshima
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  2. Daisuke Takahashi
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Correspondence to Kazunobu Toshima.

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Toshima, K., Takahashi, D. Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules. Glycoconj J 32, 475–482 (2015). https://doi.org/10.1007/s10719-015-9591-9

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  • DOI: https://doi.org/10.1007/s10719-015-9591-9

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