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Glycoconjugate Journal

, Volume 32, Issue 3–4, pp 93–103 | Cite as

Biology and biotechnology of hyaluronan

  • Manuela Viola
  • Davide Vigetti
  • Evgenia Karousou
  • Maria Luisa D’Angelo
  • Ilaria Caon
  • Paola Moretto
  • Giancarlo De Luca
  • Alberto PassiEmail author
Mini-Review

Abstract

The hyaluronan (HA) polymer is a critical component of extracellular matrix with a remarkable structure: is a linear and unbranched polymer without sulphate or phosphate groups. It is ubiquitous in mammals showing several biological functions, ranging from cell proliferation and migration to angiogenesis and inflammation. For its critical biological functions the amount of HA in tissues is carefully controlled by different mechanisms including covalent modification of the synthetic enzymes and epigenetic control of their gene expression. The concentration of HA is also critical in several pathologies including cancer, diabetes and inflammation. Beside these biological roles, the structural properties of HA allow it to take advantage of its capacity to form gels even at concentration of 1 % producing scaffolds with very promising applications in regenerative medicine as biocompatible material for advanced therapeutic uses. In this review we highlight the biological aspects of HA addressing the mechanisms controlling the HA content in tissues as well as its role in important human pathologies. In the second part of the review we highlight the different use of HA polymers in the modern biotechnology.

Keywords

Proteoglycans Glycosaminoglycans Extracellular matrix UDP-sugars O-GlcNAcylation AMPK Hydrogel 

Abbreviations

HA

Hyaluronan

UDP-GlcUA

UDP-D-glucuronic acid

UDP-GlcNAc

UDP- N-acetyl-D-glucosamine

HAS1 2 and 3

Hyaluronan synthase 1, 2 and 3

OGT

O-GlcNAc transferase

HMWHA

High molecular weight hyaluronan

LMWHA

Low molecular weight hyaluronan

ECM

Extra cellular matrix

GAG

Glycosaminoglycan

Notes

Acknowledgments

The authors acknowledge the PhD School in Biological and Medical Sciences for I.C. and M.L.D.A. fellowships, the University of Insubria FAR funds to A.P., FR/ IRSES “Inflama” project to A.P.

Disclosures

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Manuela Viola
    • 1
  • Davide Vigetti
    • 1
  • Evgenia Karousou
    • 1
  • Maria Luisa D’Angelo
    • 1
  • Ilaria Caon
    • 1
  • Paola Moretto
    • 1
  • Giancarlo De Luca
    • 1
  • Alberto Passi
    • 1
    Email author
  1. 1.Department of Surgical and Morphological SciencesUniversity of InsubriaVareseItaly

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