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Glycan microarrays of fluorescently-tagged natural glycans

  • Glycoarray Section
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Abstract

This review discusses the challenges facing research in ‘functional glycomics’ and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources, isolated and fluorescently-tagged for detailed structural analysis and for presentation on glycan microarrays for functional recognition by glycan-binding proteins. These advances in glycan preparation and manipulation enable the streamlining of functional glycomics studies and will help to propel the field forward in studying natural, biologically relevant glycans.

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Acknowledgments

The work of the authors in this area is supported by NIH Grant P41GM103694 to RDC.

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Authors and Affiliations

  1. Department of Biochemistry, The National Center for Functional Glycomics, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Xuezheng Song, Jamie Heimburg-Molinaro, David F. Smith & Richard D. Cummings

  2. Department of Biochemistry, O. Wayne Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Suite 4025, Atlanta, GA, 30322, USA

    Xuezheng Song, Jamie Heimburg-Molinaro, David F. Smith & Richard D. Cummings

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  1. Xuezheng Song
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Song, X., Heimburg-Molinaro, J., Smith, D.F. et al. Glycan microarrays of fluorescently-tagged natural glycans. Glycoconj J 32, 465–473 (2015). https://doi.org/10.1007/s10719-015-9584-8

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