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Regulation of vascular endothelial growth factor by metabolic context of the cell

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Abstract

Expression of vascular endothelial growth factor, major endothelial specific glycoprotein growth factor that promotes angiogenesis is regulated at transcriptional, post transcriptional and posttranslational levels. One of the key posttranslational modifications involved in regulating the angiogenic potential of VEGF is covalent modification involving polyADP ribosylation. Major factors contributing to the regulation of VEGF include factors relating to hypoxia, growth factors and cytokines and hormones. Apart from these, the metabolite status of the cell as sensed by various metabolite regulators can influence the angiogenic potential. Changes in the metabolite status of the cell occur during different conditions associated with excessive or insufficient angiogenesis contributing to pathology. Effect of metabolites, as exemplified by certain metabolites such as lactate, citrate, sarcosine, metabolites of arachidonic acid on angiogenesis through the regulation of expression of VEGF as well as its angiogenic potential through polyADP ribosylation is discussed.

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Acknowledgements

Financial assistance received from CSIR New Delhi to VBS Kumar, from UGC to Soumya SJ, from DST to Binu S and from KSCSTE to P R Sudhakaran is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Biochemistry & Molecular Biology, Central University of Kerala, Kasaragod, Kerala, India

    V. B. Sameer Kumar & Haritha K.

  2. Department of Biochemistry, University of Kerala, Karyavattom, Trivandrum, Kerala, India

    S. Binu, S. J. Soumya & P. R. Sudhakaran

  3. Inter-University Centre for Genomics and Gene technology, University of Kerala, Karyavattom, Trivandrum, Kerala, India

    S. J. Soumya & P. R. Sudhakaran

  4. Department of Computational Biology and Bioinformatics, University of Kerala, Karyavattom, Trivandrum, Kerala, 695 581, India

    P. R. Sudhakaran

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  1. V. B. Sameer Kumar
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Kumar, V.B.S., Binu, S., Soumya, S.J. et al. Regulation of vascular endothelial growth factor by metabolic context of the cell. Glycoconj J 31, 427–434 (2014). https://doi.org/10.1007/s10719-014-9547-5

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