Glycoconjugate Journal

, 25:157 | Cite as

Synthesis of a tetra- and a trisaccharide related to an anti-tumor saponin “Julibroside J28” from Albizia julibrissin

  • Bimalendu Roy
  • Kausikisankar Pramanik
  • Balaram MukhopadhyayEmail author


Simple and convergent synthesis of a tetra- and a trisaccharide portions of an antitumor compound Julibroside J28, isolated from Albizia julibrissin, that showed significant in vitro antitumor activity against HeLa, Bel-7402 and PC-3M-1E8 cancer cell lines is reported. The tetrasaccharide has been synthesized as its p-methoxyphenyl glycoside starting from commercially available d-glucose, l-rhamnose and l-arabinose. The trisaccharide part has been synthesized from commercially available N-acetyl d-glucosamine, d-fucose and d-xylose using simple protecting group manipulations. Sulfuric acid immobilized on silica has been used successfully as a Brönsted acid catalyst for the crucial glycosylation steps.


Saponin Synthesis H2SO4-silica Growth-inhibitory 



We thank SAIF (CDRI) for instrumental facility. BR is thankful to CSIR, New Delhi, India for fellowship. The work is funded by DST, New Delhi, India through SERC Fast-Track Grant SR/FTP/CS-110/2005.

Supporting Information Available

Experimental details and Copies of 1H and 13C spectra of all new compounds.

Supplementary material

10719_2007_9068_MOESM1_ESM.pdf (8.5 mb)
ESM 1 (PDF 8896 kb)
10719_2007_9068_MOESM2_ESM.pdf (8 mb)
ESM 2 (PDF 8366 kb)


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Bimalendu Roy
    • 1
  • Kausikisankar Pramanik
    • 2
  • Balaram Mukhopadhyay
    • 1
    Email author
  1. 1.Medicinal and Process Chemistry DivisionCentral Drug Research InstituteLucknowIndia
  2. 2.Department of Chemistry, Inorganic Chemistry SectionJadavpur UniversityJadavpurIndia

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