Whole genome approaches to quantitative genetics
- 329 Downloads
Apart from parent-offspring pairs and clones, relative pairs vary in the proportion of the genome that they share identical by descent. In the past, quantitative geneticists have used the expected value of sharing genes by descent to estimate genetic parameters and predict breeding values. With the possibility to genotype individuals for many markers across the genome it is now possible to empirically estimate the actual relationship between relatives. We review some of the theory underlying the variation in genetic identity, show applications to estimating genetic variance for height in humans and discuss other applications.
KeywordsQuantitative genetics Genome Identity-by-descent Estimation Genetic variance Actual relationship Realised relationship
We acknowledge support from the Australian National Health and Medical Research Council (grants 389892 and 442915) and the Australian Research Council (grant DP0770096), and thank Bill Hill, Mike Goddard, Nick Martin and Naomi Wray for many stimulating discussions and two referees for helpful comments.
- Bulmer MG (1985) The mathematical theory of quantitative genetics. Clarendon Press, OxfordGoogle Scholar
- Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics, 4th edn. Longman, HarlowGoogle Scholar
- Hill WG (1993a) Variation in genetic composition in backcrossing programs. J Hered 84:212–213Google Scholar
- Lynch M, Walsh B (1998) Genetics and analysis of quantitative traits. Sinauer Associates, SunderlandGoogle Scholar