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Brewer’s spent yeast replacement in carp diet leads to muscle biomass production, recycling, waste management and resource conservation

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Abstract

Brewer’s spent yeast (BSY) is among the most voluminous by-products generated in brewery industry that adds to the waste; however, smart utilization of BSY could lead to edible biomass production besides waste management. To utilize it for biomass production, it is being used in fish feeds; however, its effect on the fish physiology has been scantily studied. The present study investigated the proteomic changes in muscle tissues of carp Labeo rohita fed with BSY-based diet, to understand its impact on muscle physiology and biomass. Six feeds were prepared with different grades of BSY (0, 20, 30, 40, 50, 100% replacement of fishmeal with BSY) and fishes were fed for 90 days. Highest weight gain%, feed conversion efficiency, specific growth rate% were observed in 30% BSY–replaced group and this group was considered for the proteomic study. Comparative shotgun proteomic analysis was carried out by LC–MS/MS and data generated have been deposited in ProteomeXchange Consortium with dataset identifier PXD020093. A total of 62 proteins showed differential abundance; 29 increased and 33 decreased in the 30% BSY–replaced group. Pathway analysis using IPA and Panther tools revealed that the proteins tyrosine protein kinase, PDGFα, PKRCB and Collagen promote muscle growth by inducing the PI3K-AKT pathway. Conversely, the proteins Serine/threonine-protein phosphatase, Phosphatidylinositol 3,4,5-trisphosphate5-phosphatase 2A and Ras-specific guanine- nucleotide-releasing factor inhibit muscle growth indicating that 30% BSY–replaced feed promote muscle growth in a highly controlled manner. Findings suggest that BSY could be recycled for carp feed production in large scale thereby leading to resource conservation, reducing environmental effects.

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Data availability

Proteomic data generated in this study have been deposited in ProteomeXchange Consortium with dataset identifier PXD020093.

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Funding

KS is an Emeritus Professor at ICAR—Central Institute of Freshwater Aquaculture (CIFA), Bhubaneswar. The Indian Council of Agricultural Research supported this study under Emeritus Professor Scheme to KS. The study was also partly supported by ICAR through core-funding to CIFRI, Barrackpore (BPM). The authors (KS, DP) are thankful to the Director, CIFA, Bhubaneswar, for the facilities and encouragement.

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Author notes

  1. Bimal Prasanna Mohanty

    Present address: Indian Council of Agricultural Research, Fisheries Science Division, Krishi Anusandhan Bhawan -II, PUSA, New Delhi, 110012, India

  2. Debashish Pradhan and Arabinda Mahanty contributed equally to this work.

Authors and Affiliations

  1. ICAR-Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswer, 751002, India

    Debashish Pradhan & Kasturi Samantaray

  2. ICAR-Central Inland of Fisheries Research Institute, Barrackpore, Kolkata, India

    Arabinda Mahanty & Bimal Prasanna Mohanty

  3. ICAR-National Rice Research Institute, Crop Protection Division, Cuttack, 753006, India

    Arabinda Mahanty

  4. Faculty of Science & Technology, Department of Biotechnology, Rama Devi Women’s’ University, Bhubaneswar, 751022, India

    Sasmita Mohanty

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  1. Debashish Pradhan
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  2. Arabinda Mahanty
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  3. Sasmita Mohanty
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  5. Bimal Prasanna Mohanty
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Contributions

DP—experimental study, maintaining experimental animals, feed design, feeding trial and data analysis, manuscript preparation. AM—feeding trial, proteomic study, proteomic data analysis, data deposition, manuscript preparation and review. SM—proteomic study and proteomic data analysis, manuscript review. KS—conceptualization, funding, guidance, feed design, feeding trial and data analysis, manuscript preparation and review. BPM—conceptualization, funding, guidance, proteomic study and proteomic data analysis, manuscript preparation and review. All authors read and approved the final manuscript.

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Correspondence to Bimal Prasanna Mohanty.

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Pradhan, D., Mahanty, A., Mohanty, S. et al. Brewer’s spent yeast replacement in carp diet leads to muscle biomass production, recycling, waste management and resource conservation. Fish Physiol Biochem 48, 1427–1442 (2022). https://doi.org/10.1007/s10695-022-01133-w

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