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Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research

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Abstract

The insulin-like growth factor signalling system comprises insulin-like growth factors, insulin-like growth factor receptors and insulin-like growth factor-binding proteins. Along with the growth hormones, insulin-like growth factor signalling is very pivotal in the growth and development of all vertebrates. In fishes, insulin-like growth factors play an important role in osmoregulation, besides the neuroendocrine regulation of growth. Insulin-like growth factor concentration in plasma can assess the growth in fishes and shellfishes and therefore widely applied in nutritional research as an indicator to evaluate the performance of selected nutrients. The present review summarizes the role of insulin-like growth factor signalling in fishes and shellfishes, its significance in aquaculture and in evaluating growth, reproduction and development, and discusses the utility of this system as biomarkers for early indication of growth in aquaculture.

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Funding

This work was supported by the Centre of Excellence in Sustainable Aquaculture and Aquatic Health Management (CAAHM), Plan fund 2020–2021, Kerala University of Fisheries and Ocean Studies.

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Authors and Affiliations

  1. Centre of Excellence in Sustainable Aquaculture and Aquatic Animal Health Management (CAAHM), Department of Aquaculture, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, 682506, Kerala, India

    S. Chandhini, Bushra Trumboo & V. J. Rejish Kumar

  2. National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Kochi, 682016, Kerala, India

    Seena Jose

  3. Fish Physiology and Biochemistry Division, ICAR-Central Institute of Fisheries Education, Off-Yari Road, Versova, Andheri (W), Mumbai, 400061, India

    Tincy Varghese

  4. ICAR-Directorate of Coldwater Fisheries Research, Anusandhan Bhawan, Bhimtal, 263136, Uttarakhand, India

    M. Rajesh

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  1. S. Chandhini
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Rejish Kumar V.J, Chandhini S and Bushra Trumboo led the drafting of the manuscript, with substantial input from Seena Jose, Tincy Varghese and Rajesh M.

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Chandhini, S., Trumboo, B., Jose, S. et al. Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research. Fish Physiol Biochem 47, 1011–1031 (2021). https://doi.org/10.1007/s10695-021-00961-6

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