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n-Butyl acrylate-induced antioxidant system alteration through two generations in Oryzias latipes

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Abstract

n-Butyl acrylate (nBA) is one of acrylate esters which has been applied to diverse industrial fields. For unveiling of xeno-estrogenic effects and oxidative stress induction by nBA under two-generational exposure regimen (17 weeks), the biomarkers relevant to an estrogenic effect and oxidative stress were analyzed. Acute toxicity value of nBA in Oryzias latipes was 7.2 mg/L (96 h-LC50). Over exposure time, the significant transcriptional change of cytochrome P450 19A (CYP19A) and vitellogenin 1/2 (VTG1/2) was not observed (one-way ANOVA, P < 0.05), meaning no estrogenic effect of nBA. Significant reduction of glutathione (GSH) content was observed in F0 male and female fish, while in F1 male, the content was increased (P < 0.05). Catalase (CAT) activity of male fish showed the significant decrease in both F0 and F1 fish, showing multi-generational suppressing effect of nBA on CAT activity. But in case of reactive oxygen species (ROS), expression level and glutathione S-transferase (GST) activity were not modulated in response to nBA. These findings suggest that nBA could affect an antioxidant system alteration through GSH depletion and inhibition of CAT activity which could be transferred to the next generation, whereas xeno-estrogenic effect would be questionable.

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Funding

This work was supported by a grant from the National Institute of Environment Research (NIER), funded by the Ministry of Environment (MOE) of the Republic of Korea (ex: NIER-2016-01-01-021).

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Authors and Affiliations

  1. Risk Assessment Division, Environmental Health Research Department, National Institute of Environmental Research (NIER), Incheon, 404-708, Republic of Korea

    Jin Wuk Lee, Jae-Woo Lee, Kyungtae Kim, Yu-Jin Shin, Jieun Kim, Hokyun Kim, Heejung Kim, Su-A Min, Pilje Kim, Kyunghee Choi & Kyunghwa Park

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  1. Jin Wuk Lee
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  2. Jae-Woo Lee
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Correspondence to Kyunghwa Park.

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Lee, J.W., Lee, JW., Kim, K. et al. n-Butyl acrylate-induced antioxidant system alteration through two generations in Oryzias latipes. Fish Physiol Biochem 45, 873–883 (2019). https://doi.org/10.1007/s10695-018-0584-z

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