Effects of overfeeding and high-fat diet on cardiosomatic parameters and cardiac structures in young and adult zebrafish
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Obesity is a complex global health problem because it is a risk factor for multiple chronic pathologies such as cardiovascular, endocrine, metabolic, and neoplastic diseases. It is considered a multicausal disease, and one of the determining factors is nutritional imbalances, which include high-fat diets. In this paper, we use the zebrafish model to assess the impact of overfeeding and a high-fat diet in somatic and cardiac parameters in young and adult zebrafish. The results show that fish receiving a high-fat diet showed greater weight gain compared to fish receiving a standard fat diet. Additionally, changes in the heart, including increases in size, a change in the triangular shape of the ventricle to a globular shape, and an increase in the thickness of the trabeculae of the spongy myocardium were observed. These changes could be indicators of cardiovascular overload. The results show that there is a direct relationship between the intake of a high-fat diet and obesity, which in turn can induce cardiac changes, supporting the hypothesis of the relationship between high-fat diets and cardiovascular risk factors. Given the genetic similarity between zebrafish and humans, these results could be extrapolated to human beings, and the findings similarly highlight the importance of incorporating a balanced diet from the early life stages to reduce the risk of cardiovascular disease.
KeywordsNutrition Body mass index Obesity Myocardium Cardiovascular risk
This work was supported by Research Grant from the Pontificia Universidad Javeriana, Bogotá, Colombia. Project: 5605, budget code 120112Z0401200.
Compliance with ethical standards
No ethical issues are involved in this work.
Conflict of interest
The authors declare that they have no conflict of interest.
- Boozer CN, Schoenbach G, Atkinson RL (1995) Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically. Am J Physiol Endocrinol Metab 268(4):E546–E550Google Scholar
- Haag M, Dippenaar NG (2005) Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection. Med Sci Monit: Int Med J Exp Clin Res 11(12):RA359–RA367Google Scholar
- Kowalska A, Zakęś Z, Siwicki AK, Jankowska B, Jarmołowicz S, Demska-Zakęś K (2012) Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.) Fish Physiol Biochem 38(2):375–388. doi: 10.1007/s10695-011-9514-z CrossRefPubMedGoogle Scholar
- Leibold S, Hammerschmidt M (2015) Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction. PLoS One 10(3):e0120776. doi: 10.1371/journal.pone.0120776 CrossRefPubMedPubMedCentralGoogle Scholar
- Nekoubin H, Rakhshanipour G, Hatefi S, Sudagar M, Montajami S (2013) Effects of feeding frequency on growth performance and survival rate of zebra fish (Danio rerio). Adv J Agric Res ResearchGate 1:7–10Google Scholar
- Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, … Tanaka T (2010) Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol 10:21. doi: 10.1186/1472-6793-10-21
- Risnes KR, Vatten LJ, Baker JL, Jameson K, Sovio U, Kajantie E, … Bracken MB (2011). Birthweight and mortality in adulthood: a systematic review and meta-analysis. Int J Epidemiol 40(3):647–661. doi: 10.1093/ije/dyq267
- Singleman C, Holtzman NG (2011). Heart dissection in larval, juvenile and adult zebrafish, Danio rerio. J Vis Exp (55). doi: 10.3791/3165
- Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, … Caprio S (2004) Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350(23):2362–2374. doi: 10.1056/NEJMoa031049