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Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli

Fish Physiology and Biochemistry volume 32, pages 93–98 (2006)Cite this article

Abstract

The potential use of acetylcholinesterase (AChE) and metallothionein (MT) responses as biomarker of organophosphorous (OPs) and trace metal were assessed in fish Seriola dumerilli exposed to 0, 4, 6 mg/kg of malathion for 2, 7 and 13 days, and to 0, 50, 100, 250 μg/kg of Cd for 2 days. Brain AChE was significantly inhibited after 2 and 7 days of malathion exposure, in a dose–response manner, but no inhibition was observed after 13 days of exposure. When exposed to Cd for 2 days, S. dumerelli presented an increase in AChE activity at a concentration of 50  μg/kg, but a strong and dose-dependent AChE inhibition at 100 and 250 μg/kg. Cd treatment also caused a rapid increase in MTs concentration in liver, even at the lower concentration. Our experiments indicate that the measurement of hepatic MT concentration and brain AChE activity in S. dumerilli would be useful biomarkers of OP and Cd exposure and/or effects.

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Authors and Affiliations

  1. Laboratoire de Biochimie et de Toxicologie Environnementale, Ecole Supérieure d’Horticulture et d’Elevage, Chott-Marièm, 4042, Tunisia

    J. Jebali, M. Banni & H. Boussetta

  2. Centre de Monastir, Institut National des Sciences et Technologies de la Mer, INSTM, Monastir, Tunisia

    H. Guerbej

  3. Departamento de Química e Ciências Ambientais, IBILCE-UNESP, Rua Cristóvão Colombo, 2265, CEP 15054-000, São José do Rio Preto, SP, Brazil

    E. A. Almeida

  4. Laboratoire Eau et Environnement, Faculté des sciences, Université Ibn Izhor, Agadir, Maroc

    A. Bannaoui

Authors
  1. J. Jebali
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  2. M. Banni
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  3. H. Guerbej
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  4. E. A. Almeida
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  5. A. Bannaoui
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  6. H. Boussetta
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Correspondence to H. Boussetta.

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Jebali, J., Banni, M., Guerbej, H. et al. Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli . Fish Physiol Biochem 32, 93–98 (2006). https://doi.org/10.1007/s10695-006-0041-2

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  • DOI: https://doi.org/10.1007/s10695-006-0041-2

Keywords

  • Acetylcholinesterase
  • Biomarkers
  • Cadmium
  • Malathion
  • Metallothionein
  • Metals
  • Organophosphorous
  • Seriola dumerilli

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