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Selective ligand-binding determinants in catfish and human gonadotropin receptors

Fish Physiology and Biochemistry volume 31, pages 247–254 (2005)Cite this article

Abstract

In mammals, the specificity of FSH–FSH receptor (FSHR), LH–LH receptor (LHR) and TSH–TSH receptor couples is such that no cross-activation occurs under normal physiological conditions. The interactions between fish gonadotropins and their receptors, however, appear to be less discriminatory. For example, the catfish FSHR is highly responsive to both catfish LH and catfish FSH, while the catfish LHR is specific for its cognate LH. Comparative structure–function studies aimed at elucidating the molecular basis of ligand promiscuity (in fish) and ligand selectivity (in mammals) are described in this paper.

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References

  • Ascoli M, Fanelli F, Segaloff DL (2002) The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 23:141–174

    Article  CAS  PubMed  Google Scholar 

  • Bhowmick N, Huang J, Puett D, Isaacs NW, Lapthorn AJ (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modelling. Mol Endocrinol 10:1147–1159

    Article  CAS  PubMed  Google Scholar 

  • Bogerd J, Blomenröhr M, Andersson E, van der Putten HHAGM, Tensen CP, Vischer HF, Granneman JCM, Janssen-Dommerholt C, Goos HJTh, Schulz RW (2001) Discrepancy between molecular structure and ligand selectivity of a testicular follicle-stimulating hormone receptor of the African catfish (Clarias gariepinus). Biol Reprod 64:1633–1643

    Article  CAS  PubMed  Google Scholar 

  • Costagliola S, Urizar E, Mendive F, Vassart G (2005) Specificity and promiscuity of gonadotropin receptors. Reproduction 130:275–281

    Article  CAS  PubMed  Google Scholar 

  • Dias JA, Van Roey P (2001) Structural biology of human follitropin and its receptor. Arch Med Res 32:510–519

    Article  CAS  PubMed  Google Scholar 

  • Fan QR, Hendrickson WA (2005) Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433:269–777

    Article  CAS  PubMed  Google Scholar 

  • Ji TH, Grossmann M, Ji I (1998) G protein-coupled receptors. I. Diversity of receptor–ligand interactions. J Biol Chem 273:17299–17302

    Article  CAS  PubMed  Google Scholar 

  • Jiang X, Dreano M, Buckler DR, Cheng S, Ythier A, Wu H, Hendrickson WA, Tayar NE (1995) Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone–receptor interactions. Structure 3:1341–1353

    Article  CAS  PubMed  Google Scholar 

  • Kajava AV, Vassart G, Wodak SJ (1995) Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 3:867–877

    Article  CAS  PubMed  Google Scholar 

  • Kobe B, Deisenhofer J (1993) Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366:751–756

    Article  CAS  PubMed  Google Scholar 

  • Miwa S, Yan L, Swanson P (1994) Localization of two gonadotropin receptors in the salmon gonad by in vitro ligand autoradiography. Biol Reprod 50:629–642

    Article  CAS  PubMed  Google Scholar 

  • Moyle WR, Campbell RK, Myers RV, Bernard MP, Han Y, Wang X (1994) Coevolution of ligand–receptor pairs. Nature 368:251–255

    Article  CAS  PubMed  Google Scholar 

  • Moyle WR, Myers RV, Wang Y, Han Y, Lin W, Kelley GL, Ehrlich PH, Rao SNV, Bernard MP (1998) Functional homodimeric glycoprotein hormones: implications for hormone action and evolution. Chem Biol 5:241–254

    Article  CAS  Google Scholar 

  • Smits G, Campillo M, Govaerts C, Janssens V, Richter C, Vassart G, Pardo L, Costagliola S (2003) Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J 22:2692–2703

    Article  CAS  PubMed  Google Scholar 

  • Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002) Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure–function relationships. Physiol Rev 82:473–502

    CAS  PubMed  Google Scholar 

  • Themmen APN, Huhtaniemi IT (2000) Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 21:551–583

    Article  CAS  PubMed  Google Scholar 

  • Vischer HF, Bogerd J (2003a) Cloning and functional characterization of a gonadal luteinizing hormone receptor complementary DNA from the African catfish (Clarias gariepinus). Biol Reprod 68:262–271

    Article  CAS  Google Scholar 

  • Vischer HF, Granneman JCM, Linskens MHK, Schulz RW, Bogerd J (2003b) Both recombinant African catfish LH and FSH are able to activate the African catfish FSH receptor. J Mol Endocrinol 31:133–140

    Article  CAS  Google Scholar 

  • Vischer HF, Granneman JCM, Noordam MJ, Mosselman S, Bogerd J (2003c) Ligand selectivity of gonadotropin receptors. Role of the β-strands of extracellular leucine-rich repeats 3 and 6 of the human luteinizing hormone receptor. J Biol Chem 278:15505–15513

    Article  CAS  Google Scholar 

  • Vischer HF, Granneman JCM, Bogerd J (2003d) Opposite contribution of two ligand-selective determinants in the N-terminal hormone-binding exodomain of human gonadotropin receptors. Mol Endocrinol 17:1972–1981

    Article  CAS  Google Scholar 

  • Yan LG, Swanson P, Dickhoff WW (2002) A two-receptor model for salmon gonadotropins (GTH-I and GTH-II). Biol Reprod 47:418–427

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Endocrinology, Utrecht University, Padualaan 8, 3584, CH, Utrecht, The Netherlands

    Jan Bogerd

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  1. Jan Bogerd
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Correspondence to Jan Bogerd.

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Bogerd, J. Selective ligand-binding determinants in catfish and human gonadotropin receptors. Fish Physiol Biochem 31, 247–254 (2005). https://doi.org/10.1007/s10695-006-0032-3

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  • DOI: https://doi.org/10.1007/s10695-006-0032-3

Keywords

  • Gonadotropin receptors
  • Ligand binding
  • Structure–function relationships

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