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Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature

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Abstract

Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and hepatocellular carcinoma are rare in FAP. In this case series, we describe a mother and daughter with FAP who developed a hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas, respectively.

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA

    Jessica El Halabi

  2. Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA

    Lisa LaGuardia & David Liska

  3. Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA

    R. Matthew Walsh & Choon Hyuck David Kwon

  4. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Mail Code A30, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    K. V. Narayanan Menon & Carol A. Burke

  5. Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA

    Lisa LaGuardia, R. Matthew Walsh, David Liska & Carol A. Burke

Authors
  1. Jessica El Halabi
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  2. Lisa LaGuardia
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  3. R. Matthew Walsh
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  4. Choon Hyuck David Kwon
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  5. K. V. Narayanan Menon
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  6. David Liska
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  7. Carol A. Burke
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Contributions

CAB was involved in the conception and design of the work, critical revision of the article, and final approval of the version to be published. JEH was involved in data collection, drafting the article, critical revision of the article, and final approval of the version to be published. LL was involved in data collection, critical revision of the article, and final approval of the version to be published. RMW was involved in critical revision of the article, and final approval of the version to be published. CHDK was involved in critical revision of the article, and final approval of the version to be published. KVNM was involved in critical revision of the article, and final approval of the version to be published. DL was involved in critical revision of the article, and final approval of the version to be published.

Corresponding author

Correspondence to Carol A. Burke.

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Conflict of interest

None of the authors disclose any competing interests.

Ehical approval

Both patients were participants in the IRB approved David G. Jagelman Inherited Colorectal Cancer Registries at the Cleveland Clinic. Reference ID 2884.

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El Halabi, J., LaGuardia, L., Walsh, R.M. et al. Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature. Familial Cancer 22, 77–82 (2023). https://doi.org/10.1007/s10689-022-00305-0

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  • DOI: https://doi.org/10.1007/s10689-022-00305-0

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